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| 2022-09-10 00:00:00 | Santa Fe Zeppelins | | Promoted | Shawn Bennett II | Kansas City Wildcats |
| 2022-09-10 00:00:00 | Buenos Aires Eagles | | Promoted | Kaden Sanders | Indianapolis Tornadoes |
| 2022-09-10 00:00:00 | Indianapolis Tornadoes | | Demoted | Alexander Wasson | Buenos Aires Eagles |
| 2022-09-10 00:00:00 | Indianapolis Tornadoes | Alexander Wasson | Add/Drop | | |
| 2022-09-10 00:00:00 | Indianapolis Tornadoes | | Demoted | Kaden Sanders | Buenos Aires Eagles |
| 2022-09-10 00:00:00 | Buenos Aires Eagles | | Promoted | Kaden Sanders | Indianapolis Tornadoes |
| 2022-09-09 19:18:47 | Miami Macho Men | Gary Mitchem | Acquired via waivers | | Waiver |
| 2022-09-09 19:07:39 | San Francisco Golden Gators | Miguel Burleson | Acquired via trade | Gary Galan | Houston Octopods |
| 2022-09-09 19:07:39 | San Francisco Golden Gators | | Acquired via trade | Hunter Thomas | Houston Octopods |
| 2022-09-09 19:07:39 | San Francisco Golden Gators | | Acquired via trade | 2nd round pick in season 35 | Houston Octopods |
| 2022-09-09 19:07:39 | San Francisco Golden Gators | | Acquired via trade | 2nd round pick in season 35 | Houston Octopods |
| 2022-09-09 00:00:00 | Las Vegas Dark Knights | | Demoted | Joshua Childress | Knoxville Wampus Cats |
| 2022-09-09 00:00:00 | Las Vegas Dark Knights | | Drop | Seth Riddle | |
| 2022-09-09 00:00:00 | Kansas City Wildcats | | Drop | Nicholas Lawrence | |
| 2022-09-09 00:00:00 | Los Angeles Cacti | Joel Nobles | Add/Drop | | |
| 2022-09-09 00:00:00 | Los Angeles Cacti | | Demoted | Chandler Izzi | Quebec Buzz |
| 2022-09-09 00:00:00 | Los Angeles Cacti | Chandler Izzi | Add/Drop | Jeffrey Mitchell Jr. | |
| 2022-09-09 00:00:00 | San Diego Sabercats | Dustin Williams | Add/Drop | Sonny Kincaid | |
| 2022-09-09 00:00:00 | Los Angeles Cacti | Billy Harris | Add/Drop | Arnold Sapp | |
| 2022-09-09 00:00:00 | Los Angeles Cacti | Tyron Chan | Add/Drop | Erasmo Griffin | |
| 2022-09-09 00:00:00 | Orlando Bombers | | Drop | Wayne Salas | |
| 2022-09-09 00:00:00 | Seattle Cougars | Ronald Shelton | Add/Drop | | |
| 2022-09-08 19:54:17 | Kansas City Wildcats | Cameron Williams | Acquired via waivers | | Waiver |
| 2022-09-08 19:50:02 | Orlando Bombers | Carl Larue | Acquired via waivers | | Waiver |
| 2022-09-08 19:50:02 | Denver Ferris Wheels | Peter Fowler | Acquired via waivers | | Waiver |