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| 2022-05-01 14:09:08 | Norfolk Wolves | | Promoted | Jimmie Norwood | Dallas Hounds |
| 2022-05-01 14:08:34 | Norfolk Wolves | | Promoted | Dakota Valentine | Dallas Hounds |
| 2022-05-01 14:06:36 | Norfolk Wolves | | Promoted | Ryan Williams | Dallas Hounds |
| 2022-05-01 11:33:22 | Ottawa Mt. Hawks | | Promoted | Isaac Brown | Orlando Bombers |
| 2022-05-01 09:33:20 | Santo Domingo Lazy Dogs | | Promoted | Phillip Luck | Minneapolis Bricklayers |
| 2022-05-01 07:44:56 | Orlando Bombers | Adam Blanton | Add/Drop | | |
| 2022-05-01 07:22:12 | Louisville Colonels | | Demoted | Victor Rodrigues | Buffalo Bombers |
| 2022-05-01 07:21:42 | Buffalo Bombers | | Promoted | Robert Busch | Louisville Colonels |
| 2022-05-01 07:20:32 | Louisville Colonels | | Demoted | Nathaniel Knowles | Buffalo Bombers |
| 2022-05-01 07:20:12 | Louisville Colonels | | Demoted | Elijah Ramsey | Buffalo Bombers |
| 2022-05-01 07:19:34 | Buffalo Bombers | | Promoted | Carson Stroman | Louisville Colonels |
| 2022-05-01 07:19:14 | Buffalo Bombers | | Promoted | Colby Bowen | Louisville Colonels |
| 2022-04-30 22:46:08 | San Francisco Golden Gators | | Demoted | Daniel Ramirez | Little Rock Fighting Farmers |
| 2022-04-30 22:45:32 | San Francisco Golden Gators | | Drop | Isaiah Anderson | |
| 2022-04-30 22:44:54 | Little Rock Fighting Farmers | | Promoted | Daniel Ramirez | San Francisco Golden Gators |
| 2022-04-30 22:43:28 | San Francisco Golden Gators | | Drop | Brandon Lotz | |
| 2022-04-30 15:32:48 | Louisville Colonels | | Drop | Duane Briseno | |
| 2022-04-30 14:41:40 | Santa Fe Zeppelins | | Promoted | Alton Hambleton | Kansas City Wildcats |
| 2022-04-30 14:41:02 | Kansas City Wildcats | | Drop | Marquez Sparkman | |
| 2022-04-30 14:40:40 | Kansas City Wildcats | | Drop | Owen Stone | |
| 2022-04-30 14:39:28 | Kansas City Wildcats | | Demoted | Pedro Rice | Santa Fe Zeppelins |
| 2022-04-30 14:08:00 | San Francisco Golden Gators | 2nd round pick in season 35 | Acquired via trade | 2nd round pick in season 34 | Dallas Hounds |
| 2022-04-30 14:08:00 | San Francisco Golden Gators | Daemon Goldsberry | Acquired via trade | | Dallas Hounds |
| 2022-04-30 14:06:00 | Kansas City Wildcats | Angel Cook | Acquired via trade | 2nd round pick in season 34 | Dallas Hounds |
| 2022-04-30 14:06:00 | Kansas City Wildcats | Peyton Williams | Acquired via trade | | Dallas Hounds |