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| 2022-08-20 12:50:46 | Orlando Bombers | | Demoted | Thomas Kirk | Ottawa Mt. Hawks |
| 2022-08-20 12:50:32 | Orlando Bombers | | Demoted | Robert Fontenot | Ottawa Mt. Hawks |
| 2022-08-20 12:47:40 | Philadelphia Assassins | | Demoted | Ryan Carreno | South Dakota Blackhawks |
| 2022-08-20 12:47:28 | Philadelphia Assassins | | Demoted | Artur Swafford | South Dakota Blackhawks |
| 2022-08-20 12:39:30 | Atlanta Eels | | Demoted | Thomas Pitcher | Tampa Runner-ups |
| 2022-08-20 10:59:02 | Tampa Runner-ups | | Promoted | Dejuan Bohne | Atlanta Eels |
| 2022-08-20 10:34:42 | Philadelphia Assassins | | Demoted | Caleb Nance | South Dakota Blackhawks |
| 2022-08-20 10:34:28 | Philadelphia Assassins | | Demoted | Juan Wales | South Dakota Blackhawks |
| 2022-08-20 10:15:34 | Atlanta Eels | | Demoted | Damon Rodriguez | Tampa Runner-ups |
| 2022-08-20 07:24:00 | San Francisco Golden Gators | Jayson Forbes | Acquired via trade | Randall Ellison | Seattle Cougars |
| 2022-08-20 07:24:00 | San Francisco Golden Gators | Michael Nash | Acquired via trade | 1st round pick in season 34 | Seattle Cougars |
| 2022-08-20 04:26:12 | Vancouver Mounties | | Promoted | Vicente Fisher | Seattle Cougars |
| 2022-08-20 04:26:04 | Vancouver Mounties | | Promoted | Chad Lang | Seattle Cougars |
| 2022-08-20 04:25:50 | Seattle Cougars | | Demoted | Randall Ellison | Vancouver Mounties |
| 2022-08-19 14:36:38 | San Diego Sabercats | | Demoted | Sonny Kincaid | Santiago Sharks |
| 2022-08-18 20:24:00 | San Francisco Golden Gators | Carl Larue | Acquired via trade | Justin Cox | San Diego Sabercats |
| 2022-08-18 20:24:00 | San Francisco Golden Gators | Dewey Rodriguez | Acquired via trade | | San Diego Sabercats |
| 2022-08-18 20:16:00 | Boston Bannerman | Carlos Franklin | Acquired via trade | 2nd round pick in season 34 | San Francisco Golden Gators |
| 2022-08-18 20:16:00 | Boston Bannerman | Cesar Modica | Acquired via trade | Gary Galan | San Francisco Golden Gators |
| 2022-08-18 20:16:00 | Boston Bannerman | 3rd round pick in season 34 | Acquired via trade | | San Francisco Golden Gators |
| 2022-08-18 20:10:00 | Cincinnati Skyliners | Jacob Delgreco | Acquired via trade | Alex Mann | San Francisco Golden Gators |
| 2022-08-18 20:10:00 | Cincinnati Skyliners | Jarrod Jones | Acquired via trade | | San Francisco Golden Gators |
| 2022-08-18 19:53:32 | Philadelphia Assassins | | Demoted | Juanjose Williams | South Dakota Blackhawks |
| 2022-08-18 19:02:00 | San Francisco Golden Gators | 2nd round pick in season 35 | Acquired via trade | Juanjose Williams | Philadelphia Assassins |
| 2022-08-18 19:02:00 | San Francisco Golden Gators | David Skinner | Acquired via trade | | Philadelphia Assassins |