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| 2022-04-23 09:02:06 | Buenos Aires Eagles | | Promoted | Nicholas Greer | Indianapolis Tornadoes |
| 2022-04-23 06:56:42 | Orlando Bombers | | Drop | Ken Skelley | |
| 2022-04-23 06:49:36 | Birmingham Venom | | Promoted | Cameron Vaden | Boston Bannerman |
| 2022-04-23 06:48:26 | Birmingham Venom | | Promoted | Vinnie Peterson | Boston Bannerman |
| 2022-04-23 00:21:58 | Atlanta Eels | | Drop | Steven Brock | |
| 2022-04-22 20:14:00 | Denver Ferris Wheels | Elmer Gomez | Acquired via waivers | | Waiver |
| 2022-04-22 20:14:00 | Miami Macho Men | Herbert Trainor | Acquired via waivers | | Waiver |
| 2022-04-22 20:00:00 | San Francisco Golden Gators | 1st round pick in season 33 | Acquired via trade | 1st round pick in season 33 | Louisville Colonels |
| 2022-04-22 20:00:00 | San Francisco Golden Gators | 2nd round pick in season 33 | Acquired via trade | Mark Fisher | Louisville Colonels |
| 2022-04-22 20:00:00 | San Francisco Golden Gators | 2nd round pick in season 33 | Acquired via trade | | Louisville Colonels |
| 2022-04-22 20:00:00 | San Francisco Golden Gators | 2nd round pick in season 33 | Acquired via trade | | Louisville Colonels |
| 2022-04-22 19:08:34 | Nashville Night Owls | | Promoted | Gomer Steele | Miami Macho Men |
| 2022-04-22 19:08:00 | Miami Macho Men | Gomer Steele | Add/Drop | | |
| 2022-04-22 17:04:54 | San Antonio Brothas | Walter Henderson | Add/Drop | | |
| 2022-04-21 12:21:32 | Hartford Hebrew Hammers | | Promoted | Jack Merritt | New York Warriors |
| 2022-04-21 12:21:12 | New York Warriors | | Demoted | Joshua Langham | Hartford Hebrew Hammers |
| 2022-04-21 10:03:38 | Houston Octopods | Donald Bray | Add/Drop | | |
| 2022-04-21 10:01:32 | Denver Ferris Wheels | Jamison Whitaker | Add/Drop | | |
| 2022-04-20 14:27:30 | Houston Octopods | Stanley Wright | Add/Drop | | |
| 2022-04-20 13:58:58 | Nashville Night Owls | | Promoted | Dylan Lemire | Miami Macho Men |
| 2022-04-20 08:35:48 | Orlando Bombers | | Demoted | Ashton Kuhn | Ottawa Mt. Hawks |
| 2022-04-20 08:35:28 | Orlando Bombers | | Demoted | Isaac Brown | Ottawa Mt. Hawks |
| 2022-04-20 08:17:50 | Orlando Bombers | | Drop | Henry Knox | |
| 2022-04-20 08:16:58 | Orlando Bombers | | Drop | Walter Henderson | |
| 2022-04-19 20:39:04 | Norfolk Wolves | | Promoted | Isaac Reddington | Dallas Hounds |