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| 2022-04-19 18:43:40 | Santo Domingo Lazy Dogs | | Promoted | John McKinney | Minneapolis Bricklayers |
| 2022-04-19 14:26:18 | Denver Ferris Wheels | | Demoted | Matt Weems | Mexico City Aztecs |
| 2022-04-19 14:12:56 | Mexico City Aztecs | | Promoted | Kenneth Bell | Denver Ferris Wheels |
| 2022-04-19 14:12:50 | Mexico City Aztecs | | Promoted | Jimmy Ham | Denver Ferris Wheels |
| 2022-04-19 14:01:32 | Toronto Huskies | | Promoted | Rudy Abeyta | Salt Lake City Night Hawks |
| 2022-04-19 13:59:12 | Toronto Huskies | | Promoted | Tyler Bright | Salt Lake City Night Hawks |
| 2022-04-19 13:38:08 | Hartford Hebrew Hammers | | Promoted | Jaymes Stewart | New York Warriors |
| 2022-04-19 13:37:46 | New York Warriors | | Demoted | Jason Hancock | Hartford Hebrew Hammers |
| 2022-04-19 13:36:50 | Vancouver Mounties | | Promoted | Alex Mann | Seattle Cougars |
| 2022-04-19 13:36:42 | Vancouver Mounties | | Promoted | Jeremiah Bah | Seattle Cougars |
| 2022-04-19 13:36:32 | Vancouver Mounties | | Promoted | Chad Lang | Seattle Cougars |
| 2022-04-19 12:51:10 | Houston Octopods | | Demoted | Parker Schug | Syracuse River Rats |
| 2022-04-19 12:04:52 | Caracas Crocodiles | | Promoted | Adriel Williams | St. Louis 5th Alarm |
| 2022-04-19 12:04:38 | Caracas Crocodiles | | Promoted | Peter Crites | St. Louis 5th Alarm |
| 2022-04-18 16:58:00 | San Francisco Golden Gators | 3rd round pick in season 34 | Acquired via trade | 3rd round pick in season 33 | Boston Bannerman |
| 2022-04-18 16:52:00 | Dallas Hounds | Peyton Williams | Acquired via trade | 1st round pick in season 33 | Louisville Colonels |
| 2022-04-18 16:52:00 | Dallas Hounds | 1st round pick in season 33 | Acquired via trade | 3rd round pick in season 34 | Louisville Colonels |
| 2022-04-18 16:52:00 | Dallas Hounds | 2nd round pick in season 34 | Acquired via trade | | Louisville Colonels |
| 2022-04-18 16:52:00 | Dallas Hounds | 2nd round pick in season 33 | Acquired via trade | | Louisville Colonels |
| 2022-04-18 16:52:00 | Dallas Hounds | 2nd round pick in season 33 | Acquired via trade | | Louisville Colonels |
| 2022-04-18 16:50:00 | San Francisco Golden Gators | 3rd round pick in season 34 | Acquired via trade | 3rd round pick in season 33 | Boston Bannerman |
| 2022-04-18 15:56:38 | Philadelphia Assassins | | Demoted | Yonatan Jude | South Dakota Blackhawks |
| 2022-04-18 15:55:54 | Philadelphia Assassins | | Demoted | Ross McWhirter | South Dakota Blackhawks |
| 2022-04-18 15:55:22 | South Dakota Blackhawks | | Promoted | Valentine Lovett | Philadelphia Assassins |
| 2022-04-18 15:54:34 | South Dakota Blackhawks | | Promoted | Tyreek McGee | Philadelphia Assassins |