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| 2022-02-15 16:27:56 | Sao Paulo Jackalopes | | Promoted | Liam Kafka | Cincinnati Skyliners |
| 2022-02-15 16:21:20 | Cincinnati Skyliners | | Demoted | Alexander Mauri | Sao Paulo Jackalopes |
| 2022-02-14 20:28:42 | Buffalo Bombers | | Promoted | Colby Bowen | Louisville Colonels |
| 2022-02-14 20:27:40 | Louisville Colonels | | Demoted | John Dash | Buffalo Bombers |
| 2022-02-12 13:58:42 | Orlando Bombers | | Demoted | Hugh Wolf | Ottawa Mt. Hawks |
| 2022-02-12 13:58:06 | Orlando Bombers | | Demoted | Murray Smith | Ottawa Mt. Hawks |
| 2022-02-12 13:57:46 | Orlando Bombers | | Demoted | Jeffrey Mitchell Jr. | Ottawa Mt. Hawks |
| 2022-02-12 13:56:10 | Ottawa Mt. Hawks | | Promoted | Jared Johnson | Orlando Bombers |
| 2022-02-12 13:52:54 | Ottawa Mt. Hawks | | Promoted | Dominic Carpenter | Orlando Bombers |
| 2022-02-12 13:51:58 | Ottawa Mt. Hawks | | Promoted | Ashton Kuhn | Orlando Bombers |
| 2022-02-11 20:53:26 | Las Vegas Dark Knights | Jonathan Cole | Add/Drop | | |
| 2022-02-11 15:11:20 | Little Rock Fighting Farmers | | Promoted | Eric Spilde | San Francisco Golden Gators |
| 2022-02-11 15:11:02 | San Francisco Golden Gators | | Demoted | Mark Fisher | Little Rock Fighting Farmers |
| 2022-02-11 11:06:20 | Santo Domingo Lazy Dogs | | Promoted | John McKinney | Minneapolis Bricklayers |
| 2022-02-11 11:05:30 | Minneapolis Bricklayers | | Demoted | Jay Harzheim | Santo Domingo Lazy Dogs |
| 2022-02-10 16:39:44 | Denver Ferris Wheels | | Demoted | Lance Freeman | Mexico City Aztecs |
| 2022-02-10 16:38:46 | Mexico City Aztecs | | Promoted | Vance Hom | Denver Ferris Wheels |
| 2022-02-08 21:37:20 | Houston Octopods | | Demoted | Luis Thomason | Syracuse River Rats |
| 2022-02-08 21:36:58 | Houston Octopods | Luis Thomason | Add/Drop | Kenneth Brewster | |
| 2022-02-07 20:16:00 | Indianapolis Tornadoes | Matthew Diaz | Acquired via trade | Aaren Hintz | St. Louis 5th Alarm |
| 2022-02-07 20:16:00 | Indianapolis Tornadoes | 2nd round pick in season 33 | Acquired via trade | | St. Louis 5th Alarm |
| 2022-02-07 20:16:00 | Indianapolis Tornadoes | 3rd round pick in season 34 | Acquired via trade | | St. Louis 5th Alarm |
| 2022-02-07 20:10:00 | San Antonio Brothas | Darren Peters | Acquired via trade | 3rd round pick in season 34 | Seattle Cougars |
| 2022-02-07 16:54:44 | San Antonio Brothas | | Drop | Lamont Sanford | |
| 2022-02-07 16:45:54 | Syracuse River Rats | | Promoted | Kenneth Brewster | Houston Octopods |