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| 2022-05-31 07:32:04 | New York Warriors | | Demoted | Patrick Council | Hartford Hebrew Hammers |
| 2022-05-30 12:00:00 | Memphis Express | Shane Sandford | Acquired via trade | Louis Dominguez | St. Louis 5th Alarm |
| 2022-05-30 12:00:00 | Memphis Express | 2nd round pick in season 34 | Acquired via trade | | St. Louis 5th Alarm |
| 2022-05-30 11:51:12 | Philadelphia Assassins | | Demoted | Avery Isom | South Dakota Blackhawks |
| 2022-05-30 11:50:30 | Philadelphia Assassins | | Drop | Jose Burchfield | |
| 2022-05-30 10:40:48 | New York Warriors | | Demoted | Joshua Langham | Hartford Hebrew Hammers |
| 2022-05-30 10:40:30 | Hartford Hebrew Hammers | | Promoted | Patrick Council | New York Warriors |
| 2022-05-30 08:23:28 | Jacksonville Speed | | Promoted | Joseph Springs | Memphis Express |
| 2022-05-30 08:22:56 | Memphis Express | | Demoted | Miguel Lobue | Jacksonville Speed |
| 2022-05-30 05:20:10 | Sao Paulo Jackalopes | | Promoted | Alexander Mauri | Cincinnati Skyliners |
| 2022-05-30 05:19:52 | Cincinnati Skyliners | | Demoted | Zachary Sledge | Sao Paulo Jackalopes |
| 2022-05-29 16:16:44 | Houston Octopods | Jarrett Williams | Add/Drop | Parker Schug | |
| 2022-05-29 16:06:08 | Houston Octopods | Theo Stanton | Add/Drop | | |
| 2022-05-29 11:27:24 | Miami Macho Men | Robert Vance | Add/Drop | | |
| 2022-05-29 11:26:14 | Miami Macho Men | | Demoted | Devin Monroe | Nashville Night Owls |
| 2022-05-29 10:18:04 | Pittsburgh Berserkers | | Promoted | Chase Foster II | Cleveland Weasels |
| 2022-05-29 10:16:16 | Cleveland Weasels | | Demoted | Oscar Barton | Pittsburgh Berserkers |
| 2022-05-28 17:20:28 | New York Warriors | | Drop | John Bills | |
| 2022-05-28 14:12:24 | San Francisco Golden Gators | | Demoted | Justin Cox | Little Rock Fighting Farmers |
| 2022-05-28 14:12:16 | San Francisco Golden Gators | | Demoted | Randall Ellison | Little Rock Fighting Farmers |
| 2022-05-28 14:11:50 | Little Rock Fighting Farmers | | Promoted | Marlon Riley | San Francisco Golden Gators |
| 2022-05-28 14:11:42 | Little Rock Fighting Farmers | | Promoted | Hunter Thomas | San Francisco Golden Gators |
| 2022-05-28 11:39:58 | Caracas Crocodiles | | Promoted | Stephen Lockridge | St. Louis 5th Alarm |
| 2022-05-28 11:39:34 | St. Louis 5th Alarm | | Demoted | Nathan Stpierre | Caracas Crocodiles |
| 2022-05-28 10:36:14 | Nashville Night Owls | | Promoted | Devin Monroe | Miami Macho Men |