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| 2022-04-19 12:51:10 | Houston Octopods | | Demoted | Parker Schug | Syracuse River Rats |
| 2022-04-19 12:04:52 | Caracas Crocodiles | | Promoted | Adriel Williams | St. Louis 5th Alarm |
| 2022-04-19 12:04:38 | Caracas Crocodiles | | Promoted | Peter Crites | St. Louis 5th Alarm |
| 2022-04-18 16:58:00 | San Francisco Golden Gators | 3rd round pick in season 34 | Acquired via trade | 3rd round pick in season 33 | Boston Bannerman |
| 2022-04-18 16:52:00 | Dallas Hounds | Peyton Williams | Acquired via trade | 1st round pick in season 33 | Louisville Colonels |
| 2022-04-18 16:52:00 | Dallas Hounds | 1st round pick in season 33 | Acquired via trade | 3rd round pick in season 34 | Louisville Colonels |
| 2022-04-18 16:52:00 | Dallas Hounds | 2nd round pick in season 34 | Acquired via trade | | Louisville Colonels |
| 2022-04-18 16:52:00 | Dallas Hounds | 2nd round pick in season 33 | Acquired via trade | | Louisville Colonels |
| 2022-04-18 16:52:00 | Dallas Hounds | 2nd round pick in season 33 | Acquired via trade | | Louisville Colonels |
| 2022-04-18 16:50:00 | San Francisco Golden Gators | 3rd round pick in season 34 | Acquired via trade | 3rd round pick in season 33 | Boston Bannerman |
| 2022-04-18 15:56:38 | Philadelphia Assassins | | Demoted | Yonatan Jude | South Dakota Blackhawks |
| 2022-04-18 15:55:54 | Philadelphia Assassins | | Demoted | Ross McWhirter | South Dakota Blackhawks |
| 2022-04-18 15:55:22 | South Dakota Blackhawks | | Promoted | Valentine Lovett | Philadelphia Assassins |
| 2022-04-18 15:54:34 | South Dakota Blackhawks | | Promoted | Tyreek McGee | Philadelphia Assassins |
| 2022-04-18 08:03:42 | Indianapolis Tornadoes | | Demoted | Andres Partridge | Buenos Aires Eagles |
| 2022-04-18 08:03:26 | Buenos Aires Eagles | | Promoted | Nicholas Cook | Indianapolis Tornadoes |
| 2022-04-18 08:03:04 | Buenos Aires Eagles | | Promoted | Dane Vaden | Indianapolis Tornadoes |
| 2022-04-18 08:02:36 | Indianapolis Tornadoes | | Demoted | Ryan Cooper | Buenos Aires Eagles |
| 2022-04-18 07:54:04 | Indianapolis Tornadoes | | Demoted | Marvin Nocera | Buenos Aires Eagles |
| 2022-04-18 07:52:58 | Buenos Aires Eagles | | Promoted | M.J. Black | Indianapolis Tornadoes |
| 2022-04-17 08:41:04 | Buenos Aires Eagles | | Promoted | Marvin Nocera | Indianapolis Tornadoes |
| 2022-04-17 08:40:28 | Indianapolis Tornadoes | | Demoted | Dane Vaden | Buenos Aires Eagles |
| 2022-04-17 08:40:16 | Buenos Aires Eagles | | Promoted | Andres Partridge | Indianapolis Tornadoes |
| 2022-04-17 08:39:44 | Indianapolis Tornadoes | | Demoted | M.J. Black | Buenos Aires Eagles |
| 2022-04-16 11:06:08 | Denver Ferris Wheels | | Demoted | Chandler Hallock | Mexico City Aztecs |