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| 2021-12-30 12:22:20 | Las Vegas Dark Knights | | Drop | Richard Pope | |
| 2021-12-30 10:56:00 | Little Rock Fighting Farmers | | Promoted | CarlLee Hamilton | San Francisco Golden Gators |
| 2021-12-30 10:55:46 | San Francisco Golden Gators | | Demoted | Antonio Johnson | Little Rock Fighting Farmers |
| 2021-12-30 10:21:58 | San Francisco Golden Gators | | Demoted | Daniel Ramirez | Little Rock Fighting Farmers |
| 2021-12-30 10:16:48 | San Francisco Golden Gators | | Demoted | Mark Fisher | Little Rock Fighting Farmers |
| 2021-12-30 10:16:22 | San Francisco Golden Gators | | Demoted | Hunter Thomas | Little Rock Fighting Farmers |
| 2021-12-30 10:16:12 | San Francisco Golden Gators | | Demoted | Eric Spilde | Little Rock Fighting Farmers |
| 2021-12-30 10:15:16 | Little Rock Fighting Farmers | | Promoted | Benjamin Constant | San Francisco Golden Gators |
| 2021-12-30 08:47:26 | Seattle Cougars | | Demoted | Alex Mann | Vancouver Mounties |
| 2021-12-30 08:45:58 | Seattle Cougars | | Drop | Roland Aldridge | |
| 2021-12-30 07:22:00 | San Francisco Golden Gators | Manuel Manning | Acquired via waivers | Harrison Streater | Waiver |
| 2021-12-30 07:08:28 | Indianapolis Tornadoes | | Drop | Armando Wilson | |
| 2021-12-30 07:00:00 | San Diego Sabercats | James Dillon | Acquired via waivers | Jay Ward | Waiver |
| 2021-12-30 06:02:00 | San Francisco Golden Gators | Mark Fisher | Acquired via trade | 2nd round pick in season 33 | Seattle Cougars |
| 2021-12-30 06:02:00 | San Francisco Golden Gators | Hunter Thomas | Acquired via trade | Roland Aldridge | Seattle Cougars |
| 2021-12-30 06:02:00 | San Francisco Golden Gators | Daniel Ramirez | Acquired via trade | | Seattle Cougars |
| 2021-12-30 06:02:00 | San Francisco Golden Gators | Antonio Johnson | Acquired via trade | | Seattle Cougars |
| 2021-12-30 06:01:38 | St. Louis 5th Alarm | | Demoted | Jacob Delgreco | Caracas Crocodiles |
| 2021-12-30 06:00:00 | New York Warriors | 3rd round pick in season 34 | Acquired via trade | Jared Johnson | Orlando Bombers |
| 2021-12-30 01:35:22 | Portland Hipsters | | Drop | Austin Elliott | |
| 2021-12-30 01:04:40 | Portland Hipsters | | Drop | Antonio Young | |
| 2021-12-29 18:51:00 | Rio de Janeiro Red Storm | | Promoted | Christopher Key | Charlotte Rangers |
| 2021-12-29 18:50:30 | Charlotte Rangers | | Demoted | Michael Pauwels | Rio de Janeiro Red Storm |
| 2021-12-29 18:09:12 | Charlotte Rangers | Henry Caplinger | Add/Drop | | |
| 2021-12-29 17:33:14 | Charlotte Rangers | Tremayne Duenas | Add/Drop | | |