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| 2022-04-24 02:57:52 | New York Warriors | | Demoted | Michael Taylor | Hartford Hebrew Hammers |
| 2022-04-24 02:57:18 | New York Warriors | | Demoted | Andrew Williams | Hartford Hebrew Hammers |
| 2022-04-24 00:18:26 | Louisville Colonels | | Demoted | Leon Brown | Buffalo Bombers |
| 2022-04-23 21:56:50 | Los Angeles Cacti | | Demoted | Paul Thomas | Quebec Buzz |
| 2022-04-23 21:56:34 | Los Angeles Cacti | | Demoted | Christian Rich | Quebec Buzz |
| 2022-04-23 21:56:16 | Los Angeles Cacti | | Demoted | Fernando Jenkins | Quebec Buzz |
| 2022-04-23 18:17:44 | Green Bay Miners | | Promoted | Jordan Mason | Baltimore Miners |
| 2022-04-23 18:12:00 | Baltimore Miners | | Demoted | Gianni Boyd | Green Bay Miners |
| 2022-04-23 18:03:20 | Baltimore Miners | | Demoted | Brett Carter | Green Bay Miners |
| 2022-04-23 18:02:46 | Green Bay Miners | | Promoted | Scott Aron | Baltimore Miners |
| 2022-04-23 18:01:14 | Baltimore Miners | | Demoted | Ashton Huey | Green Bay Miners |
| 2022-04-23 17:54:42 | Baltimore Miners | Mckenzie Coleman | Add/Drop | | |
| 2022-04-23 16:21:12 | Boston Bannerman | | Demoted | Malik Griffin | Birmingham Venom |
| 2022-04-23 16:08:40 | Denver Ferris Wheels | | Demoted | Joshua Carpenter | Mexico City Aztecs |
| 2022-04-23 16:08:34 | Denver Ferris Wheels | | Demoted | Nathaniel Bradbury | Mexico City Aztecs |
| 2022-04-23 16:00:08 | Seattle Cougars | | Demoted | Harry Haley | Vancouver Mounties |
| 2022-04-23 16:00:00 | Seattle Cougars | | Demoted | Gavin Kelly | Vancouver Mounties |
| 2022-04-23 15:59:56 | Seattle Cougars | | Demoted | Aidan Dennison | Vancouver Mounties |
| 2022-04-23 15:51:42 | Atlanta Eels | | Demoted | Coleman Bowen | Tampa Runner-ups |
| 2022-04-23 15:51:22 | Tampa Runner-ups | | Promoted | Jose Thompson | Atlanta Eels |
| 2022-04-23 15:45:44 | San Francisco Golden Gators | | Demoted | David Coldwell | Little Rock Fighting Farmers |
| 2022-04-23 15:45:38 | San Francisco Golden Gators | | Demoted | Carlos Franklin | Little Rock Fighting Farmers |
| 2022-04-23 15:45:32 | San Francisco Golden Gators | | Demoted | Jarrod Jones | Little Rock Fighting Farmers |
| 2022-04-23 15:45:26 | Dallas Hounds | | Demoted | Jimmie Norwood | Norfolk Wolves |
| 2022-04-23 15:45:24 | San Francisco Golden Gators | | Demoted | Eric Simpson | Little Rock Fighting Farmers |