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| 2022-05-04 12:31:56 | Kansas City Wildcats | | Drop | Alton Hambleton | |
| 2022-05-04 12:31:36 | Kansas City Wildcats | | Drop | Scotty Skinner | |
| 2022-05-04 12:04:08 | Norfolk Wolves | | Promoted | Parker Bentley | Dallas Hounds |
| 2022-05-04 12:03:18 | Dallas Hounds | | Demoted | Dakota Valentine | Norfolk Wolves |
| 2022-05-04 11:59:28 | Dallas Hounds | | Drop | Brent Jackson | |
| 2022-05-04 11:55:12 | Dallas Hounds | | Demoted | Ryan Williams | Norfolk Wolves |
| 2022-05-04 11:54:36 | Dallas Hounds | | Drop | Jimmie Norwood | |
| 2022-05-04 10:26:02 | Indianapolis Tornadoes | | Drop | M.J. Black | |
| 2022-05-04 08:18:00 | Houston Octopods | Isaiah Anderson | Acquired via trade | David Anderson | Waiver |
| 2022-05-04 08:16:00 | Dallas Hounds | Austin Davidson | Acquired via trade | 2nd round pick in season 34 | Indianapolis Tornadoes |
| 2022-05-04 08:16:00 | Dallas Hounds | Murray Smith | Acquired via trade | | Indianapolis Tornadoes |
| 2022-05-04 08:15:38 | New Orleans Hurricanes | | Drop | David Kimble | |
| 2022-05-04 08:14:00 | Seattle Cougars | 3rd round pick in season 34 | Acquired via trade | 3rd round pick in season 34 | St. Louis 5th Alarm |
| 2022-05-04 08:14:00 | Seattle Cougars | Seven Lemay | Acquired via trade | | St. Louis 5th Alarm |
| 2022-05-04 08:12:00 | Kansas City Wildcats | Dakota Freeman | Acquired via trade | 3rd round pick in season 34 | San Francisco Golden Gators |
| 2022-05-04 08:12:00 | Kansas City Wildcats | Daniel Ramirez | Acquired via trade | | San Francisco Golden Gators |
| 2022-05-04 08:12:00 | Kansas City Wildcats | 3rd round pick in season 34 | Acquired via trade | | San Francisco Golden Gators |
| 2022-05-04 08:00:06 | New Orleans Hurricanes | | Demoted | David Kimble | Detroit Gear Daddies |
| 2022-05-04 04:57:12 | Memphis Express | | Drop | Daniel Charlot | |
| 2022-05-04 04:53:26 | Memphis Express | | Drop | Lucien Dickerson | |
| 2022-05-03 23:51:08 | Denver Ferris Wheels | | Drop | Raul Lopez | |
| 2022-05-03 21:40:34 | Las Vegas Dark Knights | | Drop | Wyatt Holloway | |
| 2022-05-03 20:35:24 | Seattle Cougars | | Drop | Johnny Pippin | |
| 2022-05-03 19:40:24 | Memphis Express | | Drop | Stanley Schwager | |
| 2022-05-03 18:49:40 | San Francisco Golden Gators | | Demoted | Richard Walker | Little Rock Fighting Farmers |