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| 2022-02-08 21:36:58 | Houston Octopods | Luis Thomason | Add/Drop | Kenneth Brewster | |
| 2022-02-07 20:16:00 | Indianapolis Tornadoes | Matthew Diaz | Acquired via trade | Aaren Hintz | St. Louis 5th Alarm |
| 2022-02-07 20:16:00 | Indianapolis Tornadoes | 2nd round pick in season 33 | Acquired via trade | | St. Louis 5th Alarm |
| 2022-02-07 20:16:00 | Indianapolis Tornadoes | 3rd round pick in season 34 | Acquired via trade | | St. Louis 5th Alarm |
| 2022-02-07 20:10:00 | San Antonio Brothas | Darren Peters | Acquired via trade | 3rd round pick in season 34 | Seattle Cougars |
| 2022-02-07 16:54:44 | San Antonio Brothas | | Drop | Lamont Sanford | |
| 2022-02-07 16:45:54 | Syracuse River Rats | | Promoted | Kenneth Brewster | Houston Octopods |
| 2022-02-07 14:09:50 | Ottawa Mt. Hawks | | Promoted | Jamal Mays | Orlando Bombers |
| 2022-02-07 14:09:28 | Orlando Bombers | | Demoted | Ken Skelley | Ottawa Mt. Hawks |
| 2022-02-07 14:09:06 | Ottawa Mt. Hawks | | Promoted | Gavin Goodson | Orlando Bombers |
| 2022-02-07 14:08:40 | Orlando Bombers | | Demoted | Jamie Gould | Ottawa Mt. Hawks |
| 2022-02-07 14:08:22 | Ottawa Mt. Hawks | | Promoted | Alex Strickland | Orlando Bombers |
| 2022-02-07 14:07:36 | Orlando Bombers | | Demoted | Dawson Fredrick | Ottawa Mt. Hawks |
| 2022-02-07 14:07:06 | Orlando Bombers | Dawson Fredrick | Add/Drop | Ricardo Ford | |
| 2022-02-05 13:30:00 | St. Louis 5th Alarm | 3rd round pick in season 34 | Acquired via trade | Darren Peters | Seattle Cougars |
| 2022-02-04 18:45:30 | Las Vegas Dark Knights | | Drop | Julius Holland | |
| 2022-02-04 18:27:52 | Orlando Bombers | Ashton Kuhn | Add/Drop | Luis Thomason | |
| 2022-02-04 16:18:02 | Louisville Colonels | Uriel Jones | Add/Drop | | |
| 2022-02-04 16:12:40 | Louisville Colonels | Peyton Williams | Add/Drop | | |
| 2022-02-04 14:34:20 | New York Warriors | | Drop | Gomer Steele | |
| 2022-02-04 14:24:00 | St. Louis 5th Alarm | Randal Golden | Acquired via trade | Jeremy Smith | Louisville Colonels |
| 2022-02-04 14:24:00 | St. Louis 5th Alarm | Peter Crites | Acquired via trade | 2nd round pick in season 33 | Louisville Colonels |
| 2022-02-04 14:20:00 | Milwaukee Sundancers | Glen Fredrickson | Acquired via trade | 2nd round pick in season 33 | Louisville Colonels |
| 2022-02-04 14:20:00 | Milwaukee Sundancers | Eugene Fitzpatrick | Acquired via trade | 2nd round pick in season 33 | Louisville Colonels |
| 2022-02-04 14:20:00 | Milwaukee Sundancers | Simeon Francois | Acquired via trade | Carson Stroman | Louisville Colonels |