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| 2021-12-21 18:34:38 | Little Rock Fighting Farmers | | Promoted | Justin Cox | San Francisco Golden Gators |
| 2021-12-21 18:34:28 | Little Rock Fighting Farmers | | Promoted | Richard Walker | San Francisco Golden Gators |
| 2021-12-21 18:33:38 | San Francisco Golden Gators | | Demoted | CarlLee Hamilton | Little Rock Fighting Farmers |
| 2021-12-21 18:33:32 | San Francisco Golden Gators | | Demoted | Larry Anderson | Little Rock Fighting Farmers |
| 2021-12-21 12:06:12 | Houston Octopods | Aaron Duong | Add/Drop | | |
| 2021-12-21 01:28:24 | Orlando Bombers | | Drop | Henry Caplinger | |
| 2021-12-21 01:12:32 | Orlando Bombers | | Drop | Alan Lee | |
| 2021-12-20 20:06:54 | Vancouver Mounties | | Promoted | Mark Fisher | Seattle Cougars |
| 2021-12-20 18:36:56 | San Diego Sabercats | | Drop | Tremayne Duenas | |
| 2021-12-20 18:30:32 | Milwaukee Sundancers | | Demoted | Richard Verble | Winnipeg Warriors |
| 2021-12-20 18:30:26 | Milwaukee Sundancers | | Demoted | Jaquez Stephenson | Winnipeg Warriors |
| 2021-12-20 18:30:20 | Milwaukee Sundancers | | Demoted | Carson Stroman | Winnipeg Warriors |
| 2021-12-20 18:30:08 | Milwaukee Sundancers | | Demoted | Jose Thompson | Winnipeg Warriors |
| 2021-12-20 18:24:08 | Santiago Sharks | | Promoted | Tremayne Duenas | San Diego Sabercats |
| 2021-12-20 18:04:16 | San Diego Sabercats | | Drop | Antonio Johnson | |
| 2021-12-20 17:58:22 | San Diego Sabercats | | Drop | James Cardillo | |
| 2021-12-20 17:57:12 | San Diego Sabercats | | Drop | Jeffrey Mitchell Jr. | |
| 2021-12-20 17:54:38 | Santiago Sharks | | Promoted | Sonny Kincaid | San Diego Sabercats |
| 2021-12-20 17:54:20 | Santiago Sharks | | Promoted | Billy Harris | San Diego Sabercats |
| 2021-12-20 17:53:02 | Santiago Sharks | | Promoted | Antonio Johnson | San Diego Sabercats |
| 2021-12-20 15:43:12 | Miami Macho Men | Herbert Trainor | Add/Drop | | |
| 2021-12-20 15:21:40 | Miami Macho Men | Larry Rizo | Add/Drop | | |
| 2021-12-20 14:43:10 | Houston Octopods | Stanley Wright | Add/Drop | | |
| 2021-12-20 12:24:36 | Orlando Bombers | | Drop | Alexis Miller | |
| 2021-12-20 06:08:14 | Philadelphia Assassins | | Demoted | Rodolfo Chu | South Dakota Blackhawks |