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| 2022-04-30 14:41:40 | Santa Fe Zeppelins | | Promoted | Alton Hambleton | Kansas City Wildcats |
| 2022-04-30 14:41:02 | Kansas City Wildcats | | Drop | Marquez Sparkman | |
| 2022-04-30 14:40:40 | Kansas City Wildcats | | Drop | Owen Stone | |
| 2022-04-30 14:39:28 | Kansas City Wildcats | | Demoted | Pedro Rice | Santa Fe Zeppelins |
| 2022-04-30 14:08:00 | San Francisco Golden Gators | 2nd round pick in season 35 | Acquired via trade | 2nd round pick in season 34 | Dallas Hounds |
| 2022-04-30 14:08:00 | San Francisco Golden Gators | Daemon Goldsberry | Acquired via trade | | Dallas Hounds |
| 2022-04-30 14:06:00 | Kansas City Wildcats | Angel Cook | Acquired via trade | 2nd round pick in season 34 | Dallas Hounds |
| 2022-04-30 14:06:00 | Kansas City Wildcats | Peyton Williams | Acquired via trade | | Dallas Hounds |
| 2022-04-30 14:06:00 | Kansas City Wildcats | Cardell Carter | Acquired via trade | | Dallas Hounds |
| 2022-04-30 11:36:18 | Philadelphia Assassins | | Drop | Yonatan Jude | |
| 2022-04-30 11:33:10 | Philadelphia Assassins | Yonatan Jude | Add/Drop | | |
| 2022-04-29 15:12:22 | Orlando Bombers | | Drop | Dominic Carpenter | |
| 2022-04-28 19:53:36 | Little Rock Fighting Farmers | | Promoted | Brandon Lotz | San Francisco Golden Gators |
| 2022-04-28 19:39:32 | Little Rock Fighting Farmers | | Promoted | Lonnie Hunt | San Francisco Golden Gators |
| 2022-04-28 19:39:26 | Little Rock Fighting Farmers | | Promoted | Isaiah Anderson | San Francisco Golden Gators |
| 2022-04-28 15:45:08 | Portland Hipsters | | Drop | Michael Parker | |
| 2022-04-28 15:41:10 | Portland Hipsters | | Demoted | Kayleb Edwards | Montreal Ice Cats |
| 2022-04-28 15:20:10 | Kansas City Wildcats | | Demoted | Jared Phillips | Santa Fe Zeppelins |
| 2022-04-28 15:18:24 | Santa Fe Zeppelins | | Promoted | Andrew Leslie | Kansas City Wildcats |
| 2022-04-28 15:12:02 | Dallas Hounds | | Drop | Alec Mor | |
| 2022-04-28 15:10:22 | Dallas Hounds | | Demoted | Jimmie Norwood | Norfolk Wolves |
| 2022-04-28 15:09:46 | Norfolk Wolves | | Promoted | Peyton Williams | Dallas Hounds |
| 2022-04-28 14:56:50 | Norfolk Wolves | | Promoted | Jimmie Norwood | Dallas Hounds |
| 2022-04-28 14:56:50 | Santa Fe Zeppelins | | Promoted | Jared Phillips | Kansas City Wildcats |
| 2022-04-28 14:56:08 | Kansas City Wildcats | | Demoted | Nicholas Lawrence | Santa Fe Zeppelins |