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| 2021-12-19 01:44:28 | St. Louis 5th Alarm | | Demoted | Cameron Williams | Caracas Crocodiles |
| 2021-12-19 01:43:52 | Caracas Crocodiles | | Promoted | Dylan McGhee | St. Louis 5th Alarm |
| 2021-12-19 01:43:16 | St. Louis 5th Alarm | | Demoted | Jacob Delgreco | Caracas Crocodiles |
| 2021-12-19 01:43:10 | St. Louis 5th Alarm | | Demoted | Jose Woods | Caracas Crocodiles |
| 2021-12-19 01:43:02 | St. Louis 5th Alarm | | Demoted | Dylan McGhee | Caracas Crocodiles |
| 2021-12-19 01:42:58 | St. Louis 5th Alarm | | Demoted | Javier Scott | Caracas Crocodiles |
| 2021-12-19 01:42:32 | Caracas Crocodiles | | Promoted | Nathan Stpierre | St. Louis 5th Alarm |
| 2021-12-18 23:31:24 | Buenos Aires Eagles | | Promoted | Sean Lutz | Indianapolis Tornadoes |
| 2021-12-18 23:13:56 | Indianapolis Tornadoes | | Demoted | Dane Vaden | Buenos Aires Eagles |
| 2021-12-18 22:59:10 | Birmingham Venom | | Promoted | Enoch Madsen | Boston Bannerman |
| 2021-12-18 20:10:00 | San Francisco Golden Gators | 2nd round pick in season 33 | Acquired via trade | K.C. Ludwig | Dallas Hounds |
| 2021-12-18 20:10:00 | San Francisco Golden Gators | Dale Charity | Acquired via trade | Madden Arellano | Dallas Hounds |
| 2021-12-18 20:10:00 | San Francisco Golden Gators | German Thompson | Acquired via trade | | Dallas Hounds |
| 2021-12-18 20:10:00 | San Francisco Golden Gators | Marlon Riley | Acquired via trade | | Dallas Hounds |
| 2021-12-18 20:10:00 | San Francisco Golden Gators | Jack Charlton | Acquired via trade | | Dallas Hounds |
| 2021-12-18 20:08:00 | Salt Lake City Night Hawks | 3rd round pick in season 33 | Acquired via trade | Jay Ward | San Diego Sabercats |
| 2021-12-18 20:06:00 | San Francisco Golden Gators | Juanjose Williams | Acquired via trade | 3rd round pick in season 33 | Dallas Hounds |
| 2021-12-18 20:06:00 | San Francisco Golden Gators | Dakota Freeman | Acquired via trade | | Dallas Hounds |
| 2021-12-18 20:04:00 | San Francisco Golden Gators | Justin Cox | Acquired via trade | Daniel Hernandez | Salt Lake City Night Hawks |
| 2021-12-18 20:04:00 | San Francisco Golden Gators | Richard Walker | Acquired via trade | | Salt Lake City Night Hawks |
| 2021-12-18 20:02:00 | San Diego Sabercats | Dylan McGhee | Acquired via trade | 3rd round pick in season 34 | St. Louis 5th Alarm |
| 2021-12-18 20:00:00 | Louisville Colonels | John Dash | Acquired via trade | Richard Armstrong | Salt Lake City Night Hawks |
| 2021-12-18 20:00:00 | Louisville Colonels | James Dillon | Acquired via trade | | Salt Lake City Night Hawks |
| 2021-12-18 20:00:00 | Louisville Colonels | 2nd round pick in season 33 | Acquired via trade | | Salt Lake City Night Hawks |
| 2021-12-18 19:00:40 | San Diego Sabercats | | Demoted | Jesus Talley | Santiago Sharks |