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| 2021-12-18 15:19:32 | Cincinnati Skyliners | | Demoted | Luis Pierre | Sao Paulo Jackalopes |
| 2021-12-18 15:15:42 | Boston Bannerman | | Demoted | Jerry Roberts | Birmingham Venom |
| 2021-12-18 14:57:12 | Buffalo Bombers | | Promoted | Eaton Harrod | Louisville Colonels |
| 2021-12-18 14:56:12 | Buffalo Bombers | | Promoted | Eugene Fitzpatrick | Louisville Colonels |
| 2021-12-18 14:55:50 | Louisville Colonels | | Demoted | Richard Armstrong | Buffalo Bombers |
| 2021-12-18 14:55:36 | Louisville Colonels | | Demoted | Robert Busch | Buffalo Bombers |
| 2021-12-18 14:31:52 | Dallas Hounds | | Demoted | Devon Hostetler | Norfolk Wolves |
| 2021-12-18 13:47:06 | Dallas Hounds | | Demoted | Lyndon Amin | Norfolk Wolves |
| 2021-12-18 13:45:54 | Norfolk Wolves | | Promoted | Isaac Reddington | Dallas Hounds |
| 2021-12-18 13:44:26 | Dallas Hounds | | Demoted | Daniel Smith | Norfolk Wolves |
| 2021-12-18 13:43:12 | Dallas Hounds | | Demoted | Marlon Riley | Norfolk Wolves |
| 2021-12-18 13:23:42 | Dallas Hounds | | Demoted | Jaheim Johnson | Norfolk Wolves |
| 2021-12-18 12:42:00 | San Diego Sabercats | Dewey Rodriguez | Acquired via trade | 1st round pick in season 32 | New York Warriors |
| 2021-12-18 12:42:00 | San Diego Sabercats | 1st round pick in season 32 | Acquired via trade | 2nd round pick in season 32 | New York Warriors |
| 2021-12-18 12:42:00 | San Diego Sabercats | 2nd round pick in season 32 | Acquired via trade | | New York Warriors |
| 2021-12-18 12:40:00 | Seattle Cougars | 1st round pick in season 32 | Acquired via trade | 1st round pick in season 33 | Atlanta Eels |
| 2021-12-18 12:40:00 | Seattle Cougars | 2nd round pick in season 32 | Acquired via trade | 2nd round pick in season 33 | Atlanta Eels |
| 2021-12-18 12:40:00 | Seattle Cougars | 2nd round pick in season 32 | Acquired via trade | | Atlanta Eels |
| 2021-12-18 12:19:22 | Dallas Hounds | | Demoted | Sean Rogers | Norfolk Wolves |
| 2021-12-18 12:19:08 | Dallas Hounds | | Demoted | Ryan Williams | Norfolk Wolves |
| 2021-12-18 11:55:56 | Dallas Hounds | | Demoted | Michael Clapper | Norfolk Wolves |
| 2021-12-18 11:55:36 | Norfolk Wolves | | Promoted | Brandon Chapman | Dallas Hounds |
| 2021-12-17 13:03:14 | Norfolk Wolves | | Promoted | Brayden Schultz | Dallas Hounds |
| 2021-12-17 13:01:04 | Norfolk Wolves | | Promoted | Michael Clapper | Dallas Hounds |
| 2021-12-17 12:58:40 | Norfolk Wolves | | Promoted | Lyndon Amin | Dallas Hounds |