|
| 2021-12-17 12:57:40 | Philadelphia Assassins | | Demoted | Xavier Wagner | South Dakota Blackhawks |
| 2021-12-17 12:53:08 | Philadelphia Assassins | | Demoted | Samuel Kinder | South Dakota Blackhawks |
| 2021-12-17 11:38:02 | Birmingham Venom | | Promoted | Brian Parris | Boston Bannerman |
| 2021-12-17 11:28:52 | Boston Bannerman | | Drop | Rick Derringer | |
| 2021-12-17 11:14:00 | Philadelphia Assassins | Joel Morrison | Acquired via trade | 1st round pick in season 32 | Dallas Hounds |
| 2021-12-17 11:14:00 | Philadelphia Assassins | John Gunderson | Acquired via trade | 2nd round pick in season 32 | Dallas Hounds |
| 2021-12-17 11:14:00 | Philadelphia Assassins | Samuel Kinder | Acquired via trade | 2nd round pick in season 33 | Dallas Hounds |
| 2021-12-17 11:14:00 | Philadelphia Assassins | 2nd round pick in season 33 | Acquired via trade | | Dallas Hounds |
| 2021-12-17 11:12:00 | Boston Bannerman | Jacob Bruno | Acquired via trade | 1st round pick in season 33 | St. Louis 5th Alarm |
| 2021-12-17 11:12:00 | Boston Bannerman | 2nd round pick in season 32 | Acquired via trade | | St. Louis 5th Alarm |
| 2021-12-17 11:10:00 | St. Louis 5th Alarm | 1st round pick in season 32 | Acquired via trade | 1st round pick in season 32 | Memphis Express |
| 2021-12-17 11:10:00 | St. Louis 5th Alarm | 2nd round pick in season 32 | Acquired via trade | Steven Reddick | Memphis Express |
| 2021-12-17 11:08:00 | New York Warriors | Kim Thue | Acquired via trade | 1st round pick in season 32 | Louisville Colonels |
| 2021-12-17 11:08:00 | New York Warriors | 3rd round pick in season 33 | Acquired via trade | 2nd round pick in season 32 | Louisville Colonels |
| 2021-12-17 10:26:08 | Little Rock Fighting Farmers | | Promoted | Isaiah Anderson | San Francisco Golden Gators |
| 2021-12-17 10:25:52 | San Francisco Golden Gators | | Demoted | Nathaniel Redd | Little Rock Fighting Farmers |
| 2021-12-14 20:37:16 | San Antonio Brothas | | Demoted | Esteban Sanchez | Calgary Cougars |
| 2021-12-14 20:37:00 | Calgary Cougars | | Promoted | Albert Reeves | San Antonio Brothas |
| 2021-12-14 20:36:54 | Calgary Cougars | | Promoted | Brady Love | San Antonio Brothas |
| 2021-12-14 20:36:40 | San Antonio Brothas | | Demoted | Jonah Bernhardt | Calgary Cougars |
| 2021-12-14 20:23:34 | St. Louis 5th Alarm | | Demoted | Jeremy Smith | Caracas Crocodiles |
| 2021-12-14 20:23:28 | St. Louis 5th Alarm | | Demoted | Edward Allen | Caracas Crocodiles |
| 2021-12-14 20:22:34 | Caracas Crocodiles | | Promoted | Edward Allen | St. Louis 5th Alarm |
| 2021-12-14 20:22:02 | Caracas Crocodiles | | Promoted | Winston Hoag | St. Louis 5th Alarm |
| 2021-12-14 14:16:18 | Philadelphia Assassins | | Demoted | Tyreek McGee | South Dakota Blackhawks |