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| 2022-02-04 14:20:00 | Milwaukee Sundancers | Glen Fredrickson | Acquired via trade | 2nd round pick in season 33 | Louisville Colonels |
| 2022-02-04 14:20:00 | Milwaukee Sundancers | Eugene Fitzpatrick | Acquired via trade | 2nd round pick in season 33 | Louisville Colonels |
| 2022-02-04 14:20:00 | Milwaukee Sundancers | Simeon Francois | Acquired via trade | Carson Stroman | Louisville Colonels |
| 2022-02-04 14:16:00 | New York Warriors | Colin Giorgi | Acquired via trade | 2nd round pick in season 33 | Louisville Colonels |
| 2022-02-04 14:16:00 | New York Warriors | 3rd round pick in season 34 | Acquired via trade | 2nd round pick in season 33 | Louisville Colonels |
| 2022-02-04 13:44:56 | Milwaukee Sundancers | | Demoted | Eugene Fitzpatrick | Winnipeg Warriors |
| 2022-02-04 13:41:14 | Milwaukee Sundancers | | Demoted | Simeon Francois | Winnipeg Warriors |
| 2022-02-04 13:16:28 | Louisville Colonels | | Demoted | Aaron Grzelak | Buffalo Bombers |
| 2022-02-04 13:15:10 | Louisville Colonels | Aaron Grzelak | Add/Drop | | |
| 2022-02-04 13:04:46 | Buffalo Bombers | | Promoted | Leonard Brown | Louisville Colonels |
| 2022-02-04 13:02:44 | Buffalo Bombers | | Promoted | John Dash | Louisville Colonels |
| 2022-02-04 13:02:24 | Buffalo Bombers | | Promoted | Greg Jobe | Louisville Colonels |
| 2022-02-04 13:02:14 | Buffalo Bombers | | Promoted | Duane Briseno | Louisville Colonels |
| 2022-02-04 05:44:14 | Louisville Colonels | Noe Brockway | Add/Drop | | |
| 2022-02-03 13:25:54 | New York Warriors | | Demoted | Austin Wyatt | Hartford Hebrew Hammers |
| 2022-02-03 13:25:34 | Hartford Hebrew Hammers | | Promoted | Gomer Steele | New York Warriors |
| 2022-02-02 19:15:06 | Green Bay Miners | | Promoted | Daron Gonsales | Baltimore Miners |
| 2022-02-02 19:14:28 | Baltimore Miners | | Demoted | John Smith | Green Bay Miners |
| 2022-02-02 19:11:38 | Green Bay Miners | | Promoted | Gerard Rowan | Baltimore Miners |
| 2022-02-02 19:10:52 | Baltimore Miners | | Demoted | Sherman Andersen | Green Bay Miners |
| 2022-02-01 20:07:54 | Norfolk Wolves | | Promoted | Norm Worm | Dallas Hounds |
| 2022-02-01 20:07:40 | Dallas Hounds | | Demoted | Isaac Reddington | Norfolk Wolves |
| 2022-01-31 20:28:00 | Milwaukee Sundancers | 2nd round pick in season 33 | Acquired via trade | Kristopher Diaz | Houston Octopods |
| 2022-01-31 16:25:06 | Houston Octopods | | Drop | Aaron Duong | |
| 2022-01-30 18:16:48 | Norfolk Wolves | | Promoted | Daemon Goldsberry | Dallas Hounds |