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| 2022-10-18 00:00:00 | Green Bay Miners | | Promoted | Brett Carter | Baltimore Miners |
| 2022-10-18 00:00:00 | Montreal Ice Cats | | Promoted | Noah Terry | Portland Hipsters |
| 2022-10-18 00:00:00 | New York Warriors | | Drop | John Bills | |
| 2022-10-13 06:37:45 | Salt Lake City Night Hawks | Joshua Williams | Acquired via trade | 1st round pick in season 36 | Miami Macho Men |
| 2022-10-13 06:37:45 | Salt Lake City Night Hawks | | Acquired via trade | 2nd round pick in season 37 | Miami Macho Men |
| 2022-10-13 06:37:45 | Salt Lake City Night Hawks | | Acquired via trade | Gino Bulloch | Miami Macho Men |
| 2022-10-13 00:00:00 | Miami Macho Men | | Drop | Gary Mitchem | |
| 2022-10-13 00:00:00 | Nashville Night Owls | | Promoted | Dylan Lemire | Miami Macho Men |
| 2022-10-13 00:00:00 | Toronto Huskies | | Promoted | Avery Klein | Salt Lake City Night Hawks |
| 2022-10-13 00:00:00 | Salt Lake City Night Hawks | | Demoted | Antonio Cox | Toronto Huskies |
| 2022-10-12 00:00:00 | Clarksville River Bandits | | Promoted | Daylon Galloway | Chicago Hilltoppers |
| 2022-10-12 00:00:00 | Winnipeg Warriors | | Promoted | Jamie Gould | Milwaukee Sundancers |
| 2022-10-12 00:00:00 | Milwaukee Sundancers | | Demoted | Derrick Jennings | Winnipeg Warriors |
| 2022-10-11 00:00:00 | Chicago Hilltoppers | | Demoted | Omar Hill | Clarksville River Bandits |
| 2022-10-09 00:00:00 | San Antonio Brothas | | Drop | Marcus Morin | |
| 2022-10-09 00:00:00 | Clarksville River Bandits | | Promoted | Spencer Cox | Chicago Hilltoppers |
| 2022-10-09 00:00:00 | Orlando Bombers | Andrew Hagan | Add/Drop | | |
| 2022-10-08 00:00:00 | Philadelphia Assassins | | Demoted | Juan Garcia | South Dakota Blackhawks |
| 2022-10-08 00:00:00 | South Dakota Blackhawks | | Promoted | Jeffrey Knight | Philadelphia Assassins |
| 2022-10-08 00:00:00 | Syracuse River Rats | | Promoted | Fred Branstetter | Houston Octopods |
| 2022-10-08 00:00:00 | Houston Octopods | | Demoted | Nasir Hardy | Syracuse River Rats |
| 2022-10-08 00:00:00 | Houston Octopods | Nasir Hardy | Add/Drop | Charlie Rigby | |
| 2022-10-07 16:35:11 | San Antonio Brothas | Joesph Hodges | Acquired via waivers | Marcus Morin | Waiver |
| 2022-10-07 00:00:00 | Hartford Hebrew Hammers | | Promoted | Andrew Williams | New York Warriors |
| 2022-10-07 00:00:00 | New York Warriors | | Demoted | Andrew Williams | Hartford Hebrew Hammers |