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| 2022-04-29 15:12:22 | Orlando Bombers | | Drop | Dominic Carpenter | |
| 2022-04-28 19:53:36 | Little Rock Fighting Farmers | | Promoted | Brandon Lotz | San Francisco Golden Gators |
| 2022-04-28 19:39:32 | Little Rock Fighting Farmers | | Promoted | Lonnie Hunt | San Francisco Golden Gators |
| 2022-04-28 19:39:26 | Little Rock Fighting Farmers | | Promoted | Isaiah Anderson | San Francisco Golden Gators |
| 2022-04-28 15:45:08 | Portland Hipsters | | Drop | Michael Parker | |
| 2022-04-28 15:41:10 | Portland Hipsters | | Demoted | Kayleb Edwards | Montreal Ice Cats |
| 2022-04-28 15:20:10 | Kansas City Wildcats | | Demoted | Jared Phillips | Santa Fe Zeppelins |
| 2022-04-28 15:18:24 | Santa Fe Zeppelins | | Promoted | Andrew Leslie | Kansas City Wildcats |
| 2022-04-28 15:12:02 | Dallas Hounds | | Drop | Alec Mor | |
| 2022-04-28 15:10:22 | Dallas Hounds | | Demoted | Jimmie Norwood | Norfolk Wolves |
| 2022-04-28 15:09:46 | Norfolk Wolves | | Promoted | Peyton Williams | Dallas Hounds |
| 2022-04-28 14:56:50 | Norfolk Wolves | | Promoted | Jimmie Norwood | Dallas Hounds |
| 2022-04-28 14:56:50 | Santa Fe Zeppelins | | Promoted | Jared Phillips | Kansas City Wildcats |
| 2022-04-28 14:56:08 | Kansas City Wildcats | | Demoted | Nicholas Lawrence | Santa Fe Zeppelins |
| 2022-04-28 14:49:40 | Dallas Hounds | | Drop | Sean Lutz | |
| 2022-04-28 14:49:16 | Dallas Hounds | | Demoted | Sean Lutz | Norfolk Wolves |
| 2022-04-28 14:48:58 | Dallas Hounds | | Drop | Cameron Ricks | |
| 2022-04-28 14:45:26 | Dallas Hounds | | Drop | Anthony Ramirez | |
| 2022-04-28 10:53:48 | New York Warriors | | Drop | Juan Powell | |
| 2022-04-28 10:53:20 | Hartford Hebrew Hammers | | Promoted | Joshua Langham | New York Warriors |
| 2022-04-28 10:50:56 | New York Warriors | | Drop | Stewart Vincent | |
| 2022-04-28 10:50:34 | New York Warriors | | Drop | Devin Ball | |
| 2022-04-28 10:44:04 | New York Warriors | | Demoted | Thomas Murdock | Hartford Hebrew Hammers |
| 2022-04-28 04:18:00 | Indianapolis Tornadoes | Murray Smith | Acquired via trade | Deep Green | Orlando Bombers |
| 2022-04-28 00:37:00 | Orlando Bombers | | Demoted | Alex Strickland | Ottawa Mt. Hawks |