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| 2021-12-18 20:06:00 | San Francisco Golden Gators | Dakota Freeman | Acquired via trade | | Dallas Hounds |
| 2021-12-18 20:04:00 | San Francisco Golden Gators | Justin Cox | Acquired via trade | Daniel Hernandez | Salt Lake City Night Hawks |
| 2021-12-18 20:04:00 | San Francisco Golden Gators | Richard Walker | Acquired via trade | | Salt Lake City Night Hawks |
| 2021-12-18 20:02:00 | San Diego Sabercats | Dylan McGhee | Acquired via trade | 3rd round pick in season 34 | St. Louis 5th Alarm |
| 2021-12-18 20:00:00 | Louisville Colonels | John Dash | Acquired via trade | Richard Armstrong | Salt Lake City Night Hawks |
| 2021-12-18 20:00:00 | Louisville Colonels | James Dillon | Acquired via trade | | Salt Lake City Night Hawks |
| 2021-12-18 20:00:00 | Louisville Colonels | 2nd round pick in season 33 | Acquired via trade | | Salt Lake City Night Hawks |
| 2021-12-18 19:00:40 | San Diego Sabercats | | Demoted | Jesus Talley | Santiago Sharks |
| 2021-12-18 18:56:22 | San Diego Sabercats | | Demoted | Charles Whitaker | Santiago Sharks |
| 2021-12-18 18:49:48 | Ottawa Mt. Hawks | | Promoted | Hugh Wolf | Orlando Bombers |
| 2021-12-18 18:49:30 | Ottawa Mt. Hawks | | Promoted | Roberto Penn | Orlando Bombers |
| 2021-12-18 18:37:12 | Indianapolis Tornadoes | | Demoted | Chandler Hallock | Buenos Aires Eagles |
| 2021-12-18 18:12:36 | San Diego Sabercats | | Demoted | Spencer Parks | Santiago Sharks |
| 2021-12-18 18:12:30 | San Diego Sabercats | | Demoted | Ryley Bland | Santiago Sharks |
| 2021-12-18 17:25:16 | Knoxville Wampus Cats | | Promoted | Neal Martin | Las Vegas Dark Knights |
| 2021-12-18 17:24:48 | Knoxville Wampus Cats | | Promoted | Rayshawn Carter | Las Vegas Dark Knights |
| 2021-12-18 17:24:08 | Las Vegas Dark Knights | | Demoted | Michael Armstrong | Knoxville Wampus Cats |
| 2021-12-18 17:23:46 | Las Vegas Dark Knights | | Demoted | Seth Riddle | Knoxville Wampus Cats |
| 2021-12-18 16:41:40 | Orlando Bombers | | Demoted | Luis Thomason | Ottawa Mt. Hawks |
| 2021-12-18 16:41:22 | Orlando Bombers | | Demoted | Raymond Bonham | Ottawa Mt. Hawks |
| 2021-12-18 16:40:50 | Orlando Bombers | | Demoted | Gavin Goodson | Ottawa Mt. Hawks |
| 2021-12-18 16:33:54 | Boston Bannerman | | Demoted | Nasir Hardy | Birmingham Venom |
| 2021-12-18 16:24:42 | Hartford Hebrew Hammers | | Promoted | Gomer Steele | New York Warriors |
| 2021-12-18 16:17:38 | New York Warriors | | Demoted | Joshua Jefferson | Hartford Hebrew Hammers |
| 2021-12-18 16:17:10 | New York Warriors | | Demoted | Trevor Doherty | Hartford Hebrew Hammers |