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| 2021-12-18 16:16:56 | New York Warriors | | Demoted | Diego Cooper | Hartford Hebrew Hammers |
| 2021-12-18 16:16:40 | New York Warriors | | Demoted | Seth Talbert | Hartford Hebrew Hammers |
| 2021-12-18 16:04:44 | Miami Macho Men | | Demoted | Reece Hicks | Nashville Night Owls |
| 2021-12-18 16:04:28 | Miami Macho Men | | Demoted | Devin Monroe | Nashville Night Owls |
| 2021-12-18 15:24:10 | Sao Paulo Jackalopes | | Promoted | Darius McVey | Cincinnati Skyliners |
| 2021-12-18 15:23:14 | Indianapolis Tornadoes | | Demoted | Andres Partridge | Buenos Aires Eagles |
| 2021-12-18 15:21:58 | Dallas Hounds | | Demoted | Cameron Ricks | Norfolk Wolves |
| 2021-12-18 15:19:48 | Cincinnati Skyliners | | Demoted | Dylan Robert | Sao Paulo Jackalopes |
| 2021-12-18 15:19:32 | Cincinnati Skyliners | | Demoted | Luis Pierre | Sao Paulo Jackalopes |
| 2021-12-18 15:15:42 | Boston Bannerman | | Demoted | Jerry Roberts | Birmingham Venom |
| 2021-12-18 14:57:12 | Buffalo Bombers | | Promoted | Eaton Harrod | Louisville Colonels |
| 2021-12-18 14:56:12 | Buffalo Bombers | | Promoted | Eugene Fitzpatrick | Louisville Colonels |
| 2021-12-18 14:55:50 | Louisville Colonels | | Demoted | Richard Armstrong | Buffalo Bombers |
| 2021-12-18 14:55:36 | Louisville Colonels | | Demoted | Robert Busch | Buffalo Bombers |
| 2021-12-18 14:31:52 | Dallas Hounds | | Demoted | Devon Hostetler | Norfolk Wolves |
| 2021-12-18 13:47:06 | Dallas Hounds | | Demoted | Lyndon Amin | Norfolk Wolves |
| 2021-12-18 13:45:54 | Norfolk Wolves | | Promoted | Isaac Reddington | Dallas Hounds |
| 2021-12-18 13:44:26 | Dallas Hounds | | Demoted | Daniel Smith | Norfolk Wolves |
| 2021-12-18 13:43:12 | Dallas Hounds | | Demoted | Marlon Riley | Norfolk Wolves |
| 2021-12-18 13:23:42 | Dallas Hounds | | Demoted | Jaheim Johnson | Norfolk Wolves |
| 2021-12-18 12:42:00 | San Diego Sabercats | Dewey Rodriguez | Acquired via trade | 1st round pick in season 32 | New York Warriors |
| 2021-12-18 12:42:00 | San Diego Sabercats | 1st round pick in season 32 | Acquired via trade | 2nd round pick in season 32 | New York Warriors |
| 2021-12-18 12:42:00 | San Diego Sabercats | 2nd round pick in season 32 | Acquired via trade | | New York Warriors |
| 2021-12-18 12:40:00 | Seattle Cougars | 1st round pick in season 32 | Acquired via trade | 1st round pick in season 33 | Atlanta Eels |
| 2021-12-18 12:40:00 | Seattle Cougars | 2nd round pick in season 32 | Acquired via trade | 2nd round pick in season 33 | Atlanta Eels |