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| 2021-12-30 07:08:28 | Indianapolis Tornadoes | | Drop | Armando Wilson | |
| 2021-12-30 07:00:00 | San Diego Sabercats | James Dillon | Acquired via waivers | Jay Ward | Waiver |
| 2021-12-30 06:02:00 | San Francisco Golden Gators | Mark Fisher | Acquired via trade | 2nd round pick in season 33 | Seattle Cougars |
| 2021-12-30 06:02:00 | San Francisco Golden Gators | Hunter Thomas | Acquired via trade | Roland Aldridge | Seattle Cougars |
| 2021-12-30 06:02:00 | San Francisco Golden Gators | Daniel Ramirez | Acquired via trade | | Seattle Cougars |
| 2021-12-30 06:02:00 | San Francisco Golden Gators | Antonio Johnson | Acquired via trade | | Seattle Cougars |
| 2021-12-30 06:01:38 | St. Louis 5th Alarm | | Demoted | Jacob Delgreco | Caracas Crocodiles |
| 2021-12-30 06:00:00 | New York Warriors | 3rd round pick in season 34 | Acquired via trade | Jared Johnson | Orlando Bombers |
| 2021-12-30 01:35:22 | Portland Hipsters | | Drop | Austin Elliott | |
| 2021-12-30 01:04:40 | Portland Hipsters | | Drop | Antonio Young | |
| 2021-12-29 18:51:00 | Rio de Janeiro Red Storm | | Promoted | Christopher Key | Charlotte Rangers |
| 2021-12-29 18:50:30 | Charlotte Rangers | | Demoted | Michael Pauwels | Rio de Janeiro Red Storm |
| 2021-12-29 18:09:12 | Charlotte Rangers | Henry Caplinger | Add/Drop | | |
| 2021-12-29 17:33:14 | Charlotte Rangers | Tremayne Duenas | Add/Drop | | |
| 2021-12-29 17:25:52 | Charlotte Rangers | | Demoted | Shawn Hudson | Rio de Janeiro Red Storm |
| 2021-12-29 05:15:24 | Mexico City Aztecs | | Promoted | Kenneth Bell | Denver Ferris Wheels |
| 2021-12-29 05:15:08 | Denver Ferris Wheels | | Demoted | Juan Goodwin | Mexico City Aztecs |
| 2021-12-29 04:23:12 | Caracas Crocodiles | | Promoted | Jacob Delgreco | St. Louis 5th Alarm |
| 2021-12-29 04:18:32 | Little Rock Fighting Farmers | | Promoted | Harrison Streater | San Francisco Golden Gators |
| 2021-12-29 04:15:26 | San Francisco Golden Gators | | Drop | Dennis Rigney | |
| 2021-12-29 04:14:52 | San Francisco Golden Gators | | Drop | Larry Anderson | |
| 2021-12-29 04:13:54 | San Francisco Golden Gators | | Drop | Jeffery Fanning | |
| 2021-12-29 04:13:26 | San Francisco Golden Gators | | Drop | Don Ostrowski | |
| 2021-12-29 02:40:04 | Orlando Bombers | | Drop | Marvin Nocera | |
| 2021-12-29 02:39:18 | Orlando Bombers | | Drop | Raymond Bonham | |