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| 2022-02-25 10:52:00 | Orlando Bombers | 2nd round pick in season 34 | Acquired via trade | Trey Binsalidh | Houston Octopods |
| 2022-02-25 09:25:22 | Orlando Bombers | | Demoted | Craig Gleason | Ottawa Mt. Hawks |
| 2022-02-25 09:25:04 | Ottawa Mt. Hawks | | Promoted | Evan Hamm | Orlando Bombers |
| 2022-02-25 09:21:54 | Orlando Bombers | Craig Gleason | Add/Drop | | |
| 2022-02-22 15:56:58 | New York Warriors | Devin Ball | Add/Drop | | |
| 2022-02-21 20:53:22 | Philadelphia Assassins | Danny Callahan | Add/Drop | Karl Coe | |
| 2022-02-21 20:28:00 | Indianapolis Tornadoes | 3rd round pick in season 33 | Acquired via trade | Theo Stanton | New York Warriors |
| 2022-02-21 19:29:08 | New York Warriors | | Drop | Christian Mallard | |
| 2022-02-21 11:02:10 | Indianapolis Tornadoes | Bourbon Mayor | Add/Drop | | |
| 2022-02-21 07:00:10 | San Francisco Golden Gators | | Demoted | Lonnie Hunt | Little Rock Fighting Farmers |
| 2022-02-21 06:59:54 | Little Rock Fighting Farmers | | Promoted | Antonio Johnson | San Francisco Golden Gators |
| 2022-02-21 00:14:38 | Quebec Buzz | | Promoted | Aaron Bowers | Los Angeles Cacti |
| 2022-02-21 00:14:08 | Los Angeles Cacti | | Demoted | Jordan Britton | Quebec Buzz |
| 2022-02-21 00:12:52 | Los Angeles Cacti | Alec Black | Add/Drop | Xavier Prall | |
| 2022-02-20 13:02:10 | New York Warriors | Christian Mallard | Add/Drop | Albert Reeves | |
| 2022-02-19 12:40:36 | Los Angeles Cacti | Tracy Stevenson | Add/Drop | | |
| 2022-02-19 12:35:12 | Los Angeles Cacti | Norberto Burgess | Add/Drop | | |
| 2022-02-19 12:24:36 | Quebec Buzz | | Promoted | Arnold Sapp | Los Angeles Cacti |
| 2022-02-19 12:24:18 | Los Angeles Cacti | | Demoted | Andres Tinsley | Quebec Buzz |
| 2022-02-19 12:07:46 | Quebec Buzz | | Promoted | Todd Shaver | Los Angeles Cacti |
| 2022-02-19 12:03:06 | Los Angeles Cacti | | Demoted | Joseph Brooks | Quebec Buzz |
| 2022-02-19 11:56:24 | Quebec Buzz | | Promoted | Xavier Prall | Los Angeles Cacti |
| 2022-02-19 11:40:12 | Quebec Buzz | | Promoted | Erasmo Griffin | Los Angeles Cacti |
| 2022-02-19 11:35:06 | Kansas City Wildcats | | Demoted | Frederick Sciortino | Santa Fe Zeppelins |
| 2022-02-19 11:31:38 | Santa Fe Zeppelins | | Promoted | James Carr | Kansas City Wildcats |