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| 2021-12-18 13:23:42 | Dallas Hounds | | Demoted | Jaheim Johnson | Norfolk Wolves |
| 2021-12-18 12:42:00 | San Diego Sabercats | Dewey Rodriguez | Acquired via trade | 1st round pick in season 32 | New York Warriors |
| 2021-12-18 12:42:00 | San Diego Sabercats | 1st round pick in season 32 | Acquired via trade | 2nd round pick in season 32 | New York Warriors |
| 2021-12-18 12:42:00 | San Diego Sabercats | 2nd round pick in season 32 | Acquired via trade | | New York Warriors |
| 2021-12-18 12:40:00 | Seattle Cougars | 1st round pick in season 32 | Acquired via trade | 1st round pick in season 33 | Atlanta Eels |
| 2021-12-18 12:40:00 | Seattle Cougars | 2nd round pick in season 32 | Acquired via trade | 2nd round pick in season 33 | Atlanta Eels |
| 2021-12-18 12:40:00 | Seattle Cougars | 2nd round pick in season 32 | Acquired via trade | | Atlanta Eels |
| 2021-12-18 12:19:22 | Dallas Hounds | | Demoted | Sean Rogers | Norfolk Wolves |
| 2021-12-18 12:19:08 | Dallas Hounds | | Demoted | Ryan Williams | Norfolk Wolves |
| 2021-12-18 11:55:56 | Dallas Hounds | | Demoted | Michael Clapper | Norfolk Wolves |
| 2021-12-18 11:55:36 | Norfolk Wolves | | Promoted | Brandon Chapman | Dallas Hounds |
| 2021-12-17 13:03:14 | Norfolk Wolves | | Promoted | Brayden Schultz | Dallas Hounds |
| 2021-12-17 13:01:04 | Norfolk Wolves | | Promoted | Michael Clapper | Dallas Hounds |
| 2021-12-17 12:58:40 | Norfolk Wolves | | Promoted | Lyndon Amin | Dallas Hounds |
| 2021-12-17 12:57:40 | Philadelphia Assassins | | Demoted | Xavier Wagner | South Dakota Blackhawks |
| 2021-12-17 12:53:08 | Philadelphia Assassins | | Demoted | Samuel Kinder | South Dakota Blackhawks |
| 2021-12-17 11:38:02 | Birmingham Venom | | Promoted | Brian Parris | Boston Bannerman |
| 2021-12-17 11:28:52 | Boston Bannerman | | Drop | Rick Derringer | |
| 2021-12-17 11:14:00 | Philadelphia Assassins | Joel Morrison | Acquired via trade | 1st round pick in season 32 | Dallas Hounds |
| 2021-12-17 11:14:00 | Philadelphia Assassins | John Gunderson | Acquired via trade | 2nd round pick in season 32 | Dallas Hounds |
| 2021-12-17 11:14:00 | Philadelphia Assassins | Samuel Kinder | Acquired via trade | 2nd round pick in season 33 | Dallas Hounds |
| 2021-12-17 11:14:00 | Philadelphia Assassins | 2nd round pick in season 33 | Acquired via trade | | Dallas Hounds |
| 2021-12-17 11:12:00 | Boston Bannerman | Jacob Bruno | Acquired via trade | 1st round pick in season 33 | St. Louis 5th Alarm |
| 2021-12-17 11:12:00 | Boston Bannerman | 2nd round pick in season 32 | Acquired via trade | | St. Louis 5th Alarm |
| 2021-12-17 11:10:00 | St. Louis 5th Alarm | 1st round pick in season 32 | Acquired via trade | 1st round pick in season 32 | Memphis Express |