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| 2021-12-17 11:10:00 | St. Louis 5th Alarm | 2nd round pick in season 32 | Acquired via trade | Steven Reddick | Memphis Express |
| 2021-12-17 11:08:00 | New York Warriors | Kim Thue | Acquired via trade | 1st round pick in season 32 | Louisville Colonels |
| 2021-12-17 11:08:00 | New York Warriors | 3rd round pick in season 33 | Acquired via trade | 2nd round pick in season 32 | Louisville Colonels |
| 2021-12-17 10:26:08 | Little Rock Fighting Farmers | | Promoted | Isaiah Anderson | San Francisco Golden Gators |
| 2021-12-17 10:25:52 | San Francisco Golden Gators | | Demoted | Nathaniel Redd | Little Rock Fighting Farmers |
| 2021-12-14 20:37:16 | San Antonio Brothas | | Demoted | Esteban Sanchez | Calgary Cougars |
| 2021-12-14 20:37:00 | Calgary Cougars | | Promoted | Albert Reeves | San Antonio Brothas |
| 2021-12-14 20:36:54 | Calgary Cougars | | Promoted | Brady Love | San Antonio Brothas |
| 2021-12-14 20:36:40 | San Antonio Brothas | | Demoted | Jonah Bernhardt | Calgary Cougars |
| 2021-12-14 20:23:34 | St. Louis 5th Alarm | | Demoted | Jeremy Smith | Caracas Crocodiles |
| 2021-12-14 20:23:28 | St. Louis 5th Alarm | | Demoted | Edward Allen | Caracas Crocodiles |
| 2021-12-14 20:22:34 | Caracas Crocodiles | | Promoted | Edward Allen | St. Louis 5th Alarm |
| 2021-12-14 20:22:02 | Caracas Crocodiles | | Promoted | Winston Hoag | St. Louis 5th Alarm |
| 2021-12-14 14:16:18 | Philadelphia Assassins | | Demoted | Tyreek McGee | South Dakota Blackhawks |
| 2021-12-12 17:13:26 | New York Warriors | | Demoted | Austin Spalding | Hartford Hebrew Hammers |
| 2021-12-12 17:13:00 | Hartford Hebrew Hammers | | Promoted | Dewey Rodriguez | New York Warriors |
| 2021-12-10 18:34:24 | Denver Ferris Wheels | | Demoted | Alec Black | Mexico City Aztecs |
| 2021-12-10 18:34:00 | Mexico City Aztecs | | Promoted | Kody Gibbs | Denver Ferris Wheels |
| 2021-12-10 18:33:12 | Denver Ferris Wheels | Alec Black | Add/Drop | | |
| 2021-12-10 18:27:54 | Denver Ferris Wheels | | Demoted | Kody Gibbs | Mexico City Aztecs |
| 2021-12-10 18:09:28 | Mexico City Aztecs | | Promoted | Kody Gibbs | Denver Ferris Wheels |
| 2021-12-10 18:09:14 | Denver Ferris Wheels | | Demoted | Lance Freeman | Mexico City Aztecs |
| 2021-12-10 15:25:54 | San Francisco Golden Gators | | Demoted | Isaiah Anderson | Little Rock Fighting Farmers |
| 2021-12-10 15:25:28 | Little Rock Fighting Farmers | | Promoted | Nathaniel Redd | San Francisco Golden Gators |
| 2021-12-10 15:25:22 | Little Rock Fighting Farmers | | Promoted | Randall Ellison | San Francisco Golden Gators |