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| 2021-08-21 15:10:00 | Orlando Bombers | 3rd round pick in season 31 | Acquired via trade | Trenton Libby | Boston Bannerman |
| 2021-08-21 15:10:00 | Orlando Bombers | 3rd round pick in season 31 | Acquired via trade | | Boston Bannerman |
| 2021-08-21 15:00:00 | Baltimore Miners | 3rd round pick in season 31 | Acquired via trade | Christopher Donaldson | Miami Macho Men |
| 2021-08-21 15:00:00 | Baltimore Miners | 1st round pick in season 32 | Acquired via trade | | Miami Macho Men |
| 2021-08-21 15:00:00 | Baltimore Miners | Jordan Mason | Acquired via trade | | Miami Macho Men |
| 2021-08-21 14:58:44 | Portland Hipsters | | Demoted | Antonio Young | Montreal Ice Cats |
| 2021-08-21 14:58:38 | Portland Hipsters | | Demoted | Tanner Sirmans | Montreal Ice Cats |
| 2021-08-21 14:58:32 | Portland Hipsters | | Demoted | Jonathan Cole | Montreal Ice Cats |
| 2021-08-21 14:58:16 | Portland Hipsters | | Demoted | Moshe Richardson | Montreal Ice Cats |
| 2021-08-21 14:58:06 | Portland Hipsters | | Demoted | Noah Terry | Montreal Ice Cats |
| 2021-08-21 14:42:12 | Boston Bannerman | | Demoted | Michael Holt | Birmingham Venom |
| 2021-08-21 14:39:52 | Boston Bannerman | | Demoted | Joshua Whalen | Birmingham Venom |
| 2021-08-21 14:38:44 | Boston Bannerman | | Demoted | Harold Lewis | Birmingham Venom |
| 2021-08-21 14:30:14 | Louisville Colonels | | Demoted | Colby Bowen | Buffalo Bombers |
| 2021-08-21 14:30:04 | Louisville Colonels | | Demoted | Brian Thomas | Buffalo Bombers |
| 2021-08-21 14:29:50 | Louisville Colonels | | Demoted | Ethan Derose | Buffalo Bombers |
| 2021-08-21 13:42:36 | Atlanta Eels | | Demoted | Rene Keller | Tampa Runner-ups |
| 2021-08-21 12:43:42 | Atlanta Eels | | Demoted | Justin McInnis | Tampa Runner-ups |
| 2021-08-21 12:08:36 | Indianapolis Tornadoes | | Demoted | Derrick Gonzalez | Buenos Aires Eagles |
| 2021-08-21 12:07:50 | Orlando Bombers | | Demoted | Alex Strickland | Ottawa Mt. Hawks |
| 2021-08-21 10:35:44 | Atlanta Eels | | Demoted | Samuel Fowler | Tampa Runner-ups |
| 2021-08-21 10:28:00 | New York Warriors | Guy Fink | Acquired via trade | Isaac Brown | San Diego Sabercats |
| 2021-08-21 10:28:00 | New York Warriors | Stanley Wright | Acquired via trade | | San Diego Sabercats |
| 2021-08-21 10:20:00 | Seattle Cougars | 2nd round pick in season 31 | Acquired via trade | 2nd round pick in season 32 | St. Louis 5th Alarm |
| 2021-08-21 10:20:00 | Seattle Cougars | 3rd round pick in season 31 | Acquired via trade | | St. Louis 5th Alarm |