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| 2021-08-25 02:22:50 | Cincinnati Skyliners | | Demoted | Daniel Allen | Cincinnati Skyliners |
| 2021-08-24 23:08:00 | Orlando Bombers | Roberto Penn | Acquired via waivers | | Waiver |
| 2021-08-24 22:52:00 | Dallas Hounds | Dane Vaden | Acquired via trade | Jason Hancock | New Orleans Hurricanes |
| 2021-08-24 22:52:00 | Dallas Hounds | 2nd round pick in season 32 | Acquired via trade | 2nd round pick in season 32 | New Orleans Hurricanes |
| 2021-08-24 22:50:00 | Boston Bannerman | Steven Brock | Acquired via trade | 2nd round pick in season 33 | Salt Lake City Night Hawks |
| 2021-08-24 22:50:00 | Boston Bannerman | Rick Derringer | Acquired via trade | | Salt Lake City Night Hawks |
| 2021-08-24 19:04:20 | Salt Lake City Night Hawks | Jorge Gividen | Add/Drop | | |
| 2021-08-24 17:52:28 | Salt Lake City Night Hawks | | Drop | Tony Piantik | |
| 2021-08-24 13:57:50 | Miami Macho Men | | Demoted | Ahmad Raber | Nashville Night Owls |
| 2021-08-24 13:48:58 | Nashville Night Owls | | Promoted | Robert Gregory | Miami Macho Men |
| 2021-08-24 13:28:08 | Miami Macho Men | Ahmad Raber | Add/Drop | | |
| 2021-08-24 12:51:58 | Nashville Night Owls | | Promoted | Trevor Brewster | Miami Macho Men |
| 2021-08-24 12:51:26 | Nashville Night Owls | | Promoted | Zachary Bell | Miami Macho Men |
| 2021-08-24 11:04:00 | Philadelphia Assassins | Yonatan Jude | Acquired via waivers | | Waiver |
| 2021-08-24 11:02:00 | Cleveland Weasels | Edward Dupree | Acquired via waivers | | Waiver |
| 2021-08-24 11:00:00 | Cleveland Weasels | Rahim Hughes | Acquired via waivers | | Waiver |
| 2021-08-24 10:58:00 | Orlando Bombers | Kirby Jeanbaptiste | Acquired via waivers | | Waiver |
| 2021-08-24 10:56:00 | Philadelphia Assassins | Anthony Burns | Acquired via waivers | | Waiver |
| 2021-08-24 10:54:00 | Baltimore Miners | Daron Gonsales | Acquired via waivers | | Waiver |
| 2021-08-24 08:40:12 | Orlando Bombers | | Demoted | Kirby Jeanbaptiste | Ottawa Mt. Hawks |
| 2021-08-23 20:39:06 | Denver Ferris Wheels | | Demoted | Vance Hom | Mexico City Aztecs |
| 2021-08-23 20:37:02 | Mexico City Aztecs | | Promoted | Vance Hom | Denver Ferris Wheels |
| 2021-08-23 20:35:52 | Denver Ferris Wheels | | Demoted | Sean Naughton | Mexico City Aztecs |
| 2021-08-23 20:01:44 | Denver Ferris Wheels | | Demoted | Adam Blanton | Mexico City Aztecs |
| 2021-08-23 20:01:26 | Mexico City Aztecs | | Promoted | Juan Powell | Denver Ferris Wheels |