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| 2021-08-21 10:14:00 | St. Louis 5th Alarm | 1st round pick in season 31 | Acquired via trade | Elmer Robinson | San Diego Sabercats |
| 2021-08-21 10:10:00 | Louisville Colonels | 2nd round pick in season 31 | Acquired via trade | 2nd round pick in season 33 | New York Warriors |
| 2021-08-21 10:10:00 | Louisville Colonels | 2nd round pick in season 31 | Acquired via trade | | New York Warriors |
| 2021-08-21 10:10:00 | Louisville Colonels | 3rd round pick in season 31 | Acquired via trade | | New York Warriors |
| 2021-08-21 09:51:20 | Atlanta Eels | | Drop | Brady Lasley | |
| 2021-08-21 05:56:54 | Knoxville Wampus Cats | | Promoted | James Vieira | Las Vegas Dark Knights |
| 2021-08-21 05:56:08 | Knoxville Wampus Cats | | Promoted | Adolph Cox | Las Vegas Dark Knights |
| 2021-08-20 16:36:00 | New York Warriors | Christian Mallard | Add/Drop | Patrick Magee | |
| 2021-08-20 16:31:48 | New York Warriors | Patrick Magee | Add/Drop | | |
| 2021-08-20 16:25:48 | New York Warriors | Daniel Dukes | Add/Drop | | |
| 2021-08-20 14:42:38 | New York Warriors | | Demoted | Joseph Jackson | Hartford Hebrew Hammers |
| 2021-08-20 10:50:00 | San Diego Sabercats | Jacob Dolan | Acquired via trade | Glen Jackson | Dallas Hounds |
| 2021-08-20 10:50:00 | San Diego Sabercats | Austin Wyatt | Acquired via trade | 1st round pick in season 31 | Dallas Hounds |
| 2021-08-20 10:50:00 | San Diego Sabercats | 2nd round pick in season 32 | Acquired via trade | | Dallas Hounds |
| 2021-08-20 10:43:42 | San Diego Sabercats | | Demoted | Jacob Dolan | Santiago Sharks |
| 2021-08-20 10:26:00 | Boston Bannerman | Anthony Green | Acquired via trade | 1st round pick in season 32 | New York Warriors |
| 2021-08-20 10:26:00 | Boston Bannerman | Brian Parris | Acquired via trade | Jacob Williams | New York Warriors |
| 2021-08-20 10:26:00 | Boston Bannerman | Jean Quinn | Acquired via trade | 3rd round pick in season 33 | New York Warriors |
| 2021-08-20 10:26:00 | Boston Bannerman | 1st round pick in season 31 | Acquired via trade | | New York Warriors |
| 2021-08-20 09:39:52 | Boston Bannerman | | Demoted | Maximus Harris | Birmingham Venom |
| 2021-08-20 09:39:40 | Boston Bannerman | | Demoted | Anthony Green | Birmingham Venom |
| 2021-08-20 08:55:34 | Norfolk Wolves | | Promoted | Brandon Chapman | Dallas Hounds |
| 2021-08-19 14:53:28 | Sao Paulo Jackalopes | | Promoted | Jonathan Ott | Cincinnati Skyliners |
| 2021-08-19 14:50:26 | Cincinnati Skyliners | | Demoted | Kaden Sanders | Sao Paulo Jackalopes |
| 2021-08-19 13:57:22 | New York Warriors | | Demoted | Jacob Larkins | Hartford Hebrew Hammers |