| 2021-09-05 11:19:48 | Orlando Bombers | | Demoted | Carl Kraker | Ottawa Mt. Hawks |
| 2021-09-05 11:19:30 | Ottawa Mt. Hawks | | Promoted | Dashawn Head | Orlando Bombers |
| 2021-09-05 09:27:48 | Chicago Hilltoppers | | Demoted | Kobe Terrell | Clarksville River Bandits |
| 2021-09-05 09:10:48 | San Francisco Golden Gators | | Drop | Dennis Rigney | |
| 2021-09-05 09:03:22 | Houston Octopods | | Drop | Hugo Eads | |
| 2021-09-05 08:57:02 | San Francisco Golden Gators | | Demoted | Randall Ellison | Little Rock Fighting Farmers |
| 2021-09-05 08:52:14 | San Francisco Golden Gators | | Demoted | Scott Mendez | Little Rock Fighting Farmers |
| 2021-09-04 20:00:00 | Seattle Cougars | | Drop | Rubin Elwood | |
| 2021-09-04 19:40:00 | Denver Ferris Wheels | Saer Sene | Acquired via waivers | Clarence Whaley | Waiver |
| 2021-09-04 16:32:16 | New Orleans Hurricanes | | Drop | Peyton Williams | |
| 2021-09-04 16:28:54 | New Orleans Hurricanes | | Drop | Alexis Miller | |
| 2021-09-04 16:25:16 | Mexico City Aztecs | | Promoted | Juan Powell | Denver Ferris Wheels |
| 2021-09-04 16:24:58 | Denver Ferris Wheels | | Demoted | Juan Goodwin | Mexico City Aztecs |
| 2021-09-04 15:56:26 | Vancouver Mounties | | Promoted | Michael Nash | Seattle Cougars |
| 2021-09-04 12:56:22 | Santiago Sharks | | Promoted | Antonio Johnson | San Diego Sabercats |
| 2021-09-03 22:53:18 | San Diego Sabercats | | Drop | Michael Arnold | |
| 2021-09-03 21:15:08 | Kansas City Wildcats | | Drop | Marquez Sparkman | |
| 2021-09-03 21:14:40 | Kansas City Wildcats | | Demoted | Cody Grabowski | Santa Fe Zeppelins |
| 2021-09-03 21:02:20 | Kansas City Wildcats | | Drop | Paris Wheat | |
| 2021-09-03 21:00:18 | Kansas City Wildcats | | Demoted | Miles Russell | Santa Fe Zeppelins |
| 2021-09-03 20:49:02 | Kansas City Wildcats | | Drop | Aaron Duong | |
| 2021-09-03 20:46:00 | Kansas City Wildcats | | Drop | Martin Solomon | |
| 2021-09-03 20:45:36 | Kansas City Wildcats | | Drop | Wilton Feldt | |
| 2021-09-03 20:16:04 | Kansas City Wildcats | | Drop | Oscar Rouse | |
| 2021-09-03 20:13:20 | Kansas City Wildcats | | Demoted | Owen Stone | Santa Fe Zeppelins |