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| 2021-12-30 17:34:58 | San Diego Sabercats | | Drop | Isaac Brown | |
| 2021-12-30 14:13:50 | Miami Macho Men | | Demoted | Dylan Lemire | Nashville Night Owls |
| 2021-12-30 13:18:54 | Toronto Huskies | | Promoted | Rudy Abeyta | Salt Lake City Night Hawks |
| 2021-12-30 13:06:34 | Milwaukee Sundancers | | Drop | Clifford Clark | |
| 2021-12-30 13:05:56 | Milwaukee Sundancers | | Drop | Sylvester Dixon | |
| 2021-12-30 12:49:52 | Milwaukee Sundancers | | Drop | Richard Verble | |
| 2021-12-30 12:48:08 | Milwaukee Sundancers | | Drop | Norberto Burgess | |
| 2021-12-30 12:42:14 | Milwaukee Sundancers | | Demoted | Jamarcus Buckles | Winnipeg Warriors |
| 2021-12-30 12:42:06 | Milwaukee Sundancers | | Demoted | Christopher Brooks | Winnipeg Warriors |
| 2021-12-30 12:26:28 | Milwaukee Sundancers | | Drop | Connor Frye | |
| 2021-12-30 12:22:20 | Las Vegas Dark Knights | | Drop | Richard Pope | |
| 2021-12-30 10:56:00 | Little Rock Fighting Farmers | | Promoted | CarlLee Hamilton | San Francisco Golden Gators |
| 2021-12-30 10:55:46 | San Francisco Golden Gators | | Demoted | Antonio Johnson | Little Rock Fighting Farmers |
| 2021-12-30 10:21:58 | San Francisco Golden Gators | | Demoted | Daniel Ramirez | Little Rock Fighting Farmers |
| 2021-12-30 10:16:48 | San Francisco Golden Gators | | Demoted | Mark Fisher | Little Rock Fighting Farmers |
| 2021-12-30 10:16:22 | San Francisco Golden Gators | | Demoted | Hunter Thomas | Little Rock Fighting Farmers |
| 2021-12-30 10:16:12 | San Francisco Golden Gators | | Demoted | Eric Spilde | Little Rock Fighting Farmers |
| 2021-12-30 10:15:16 | Little Rock Fighting Farmers | | Promoted | Benjamin Constant | San Francisco Golden Gators |
| 2021-12-30 08:47:26 | Seattle Cougars | | Demoted | Alex Mann | Vancouver Mounties |
| 2021-12-30 08:45:58 | Seattle Cougars | | Drop | Roland Aldridge | |
| 2021-12-30 07:22:00 | San Francisco Golden Gators | Manuel Manning | Acquired via waivers | Harrison Streater | Waiver |
| 2021-12-30 07:08:28 | Indianapolis Tornadoes | | Drop | Armando Wilson | |
| 2021-12-30 07:00:00 | San Diego Sabercats | James Dillon | Acquired via waivers | Jay Ward | Waiver |
| 2021-12-30 06:02:00 | San Francisco Golden Gators | Mark Fisher | Acquired via trade | 2nd round pick in season 33 | Seattle Cougars |
| 2021-12-30 06:02:00 | San Francisco Golden Gators | Hunter Thomas | Acquired via trade | Roland Aldridge | Seattle Cougars |