|
| 2021-05-01 04:00:28 | San Antonio Brothas | | Demoted | Larry Anderson | Calgary Cougars |
| 2021-05-01 04:00:22 | San Antonio Brothas | | Demoted | Roy Schiefelbein | Calgary Cougars |
| 2021-04-30 16:40:00 | Seattle Cougars | Charlie Rigby | Acquired via trade | Sean Crafton | Philadelphia Assassins |
| 2021-04-30 16:40:00 | Seattle Cougars | 2nd round pick in season 31 | Acquired via trade | 2nd round pick in season 31 | Philadelphia Assassins |
| 2021-04-30 14:55:06 | South Dakota Blackhawks | | Promoted | Jason Taylor | Philadelphia Assassins |
| 2021-04-30 14:54:08 | Philadelphia Assassins | | Demoted | Tyler Maddox | South Dakota Blackhawks |
| 2021-04-30 14:52:22 | Philadelphia Assassins | Tyler Maddox | Add/Drop | | |
| 2021-04-30 14:21:42 | Philadelphia Assassins | | Demoted | Ross McWhirter | South Dakota Blackhawks |
| 2021-04-30 14:12:28 | Philadelphia Assassins | Ross McWhirter | Add/Drop | | |
| 2021-04-30 14:01:10 | South Dakota Blackhawks | | Promoted | Dashawn Shellenbarger | Philadelphia Assassins |
| 2021-04-30 13:47:00 | Orlando Bombers | | Drop | Kurt Phillips | |
| 2021-04-30 13:44:34 | Orlando Bombers | | Drop | Howard Halton | |
| 2021-04-30 13:20:28 | San Francisco Golden Gators | | Drop | Carson Boling | |
| 2021-04-30 13:20:08 | San Francisco Golden Gators | | Drop | Gerald Campbell | |
| 2021-04-30 13:19:32 | San Francisco Golden Gators | | Drop | Bruce Sutphin | |
| 2021-04-30 13:15:58 | Philadelphia Assassins | | Demoted | Jason Taylor | South Dakota Blackhawks |
| 2021-04-30 13:14:58 | South Dakota Blackhawks | | Promoted | David Anderson | Philadelphia Assassins |
| 2021-04-30 08:43:24 | Boston Bannerman | | Demoted | Gary Galan | Birmingham Venom |
| 2021-04-30 04:35:16 | Miami Macho Men | | Drop | Patrick Overton | |
| 2021-04-30 04:33:36 | Miami Macho Men | | Demoted | Kyre Sanders | Nashville Night Owls |
| 2021-04-29 22:18:00 | San Diego Sabercats | Thomas Cox | Acquired via waivers | | Waiver |
| 2021-04-29 22:02:00 | Denver Ferris Wheels | Vance Hom | Acquired via trade | 2nd round pick in season 31 | St. Louis 5th Alarm |
| 2021-04-29 22:02:00 | Denver Ferris Wheels | Jeffrey Otoole | Acquired via trade | 3rd round pick in season 31 | St. Louis 5th Alarm |
| 2021-04-29 22:02:00 | Denver Ferris Wheels | Ricardo Mckeown | Acquired via trade | | St. Louis 5th Alarm |
| 2021-04-29 22:02:00 | Denver Ferris Wheels | 3rd round pick in season 31 | Acquired via trade | | St. Louis 5th Alarm |