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| 2021-06-30 00:47:38 | Santiago Sharks | | Promoted | Gehrig Jones | San Diego Sabercats |
| 2021-06-30 00:34:52 | San Diego Sabercats | | Demoted | Christopher Adams | Santiago Sharks |
| 2021-06-30 00:32:50 | Santiago Sharks | | Promoted | Christopher Burke | San Diego Sabercats |
| 2021-06-30 00:32:24 | Santiago Sharks | | Promoted | Tremayne Duenas | San Diego Sabercats |
| 2021-06-30 00:32:08 | Santiago Sharks | | Promoted | Glen Jackson | San Diego Sabercats |
| 2021-06-30 00:19:16 | San Diego Sabercats | | Demoted | Andrew Deguire | Santiago Sharks |
| 2021-06-29 17:26:14 | Buenos Aires Eagles | | Promoted | Roberto Morse | Indianapolis Tornadoes |
| 2021-06-29 17:25:44 | Indianapolis Tornadoes | | Demoted | Armando Wilson | Buenos Aires Eagles |
| 2021-06-29 14:43:28 | South Dakota Blackhawks | | Promoted | Sherman Atkinson | Philadelphia Assassins |
| 2021-06-29 14:43:02 | Philadelphia Assassins | | Demoted | Valentine Lovett | South Dakota Blackhawks |
| 2021-06-28 23:16:22 | Louisville Colonels | | Drop | Claude Rodriguez | |
| 2021-06-28 14:58:10 | South Dakota Blackhawks | | Promoted | Chad Hammond | Philadelphia Assassins |
| 2021-06-28 14:57:48 | Philadelphia Assassins | | Demoted | Jeffrey Knight | South Dakota Blackhawks |
| 2021-06-28 03:23:50 | Denver Ferris Wheels | | Drop | Benny Ward | |
| 2021-06-27 21:09:14 | Boston Bannerman | Lamar Hellmann | Add/Drop | Emmanuel Guidry | |
| 2021-06-27 20:54:00 | Louisville Colonels | Randal Golden | Acquired via trade | 1st round pick in season 31 | San Diego Sabercats |
| 2021-06-27 15:30:08 | Buenos Aires Eagles | | Promoted | M.J. Black | Indianapolis Tornadoes |
| 2021-06-27 15:29:50 | Indianapolis Tornadoes | | Demoted | Alfred Irby | Buenos Aires Eagles |
| 2021-06-27 14:51:00 | Little Rock Fighting Farmers | | Promoted | Victor Rodrigues | San Francisco Golden Gators |
| 2021-06-27 14:50:42 | San Francisco Golden Gators | | Demoted | Devin Ball | Little Rock Fighting Farmers |
| 2021-06-27 14:49:42 | Little Rock Fighting Farmers | | Promoted | CarlLee Hamilton | San Francisco Golden Gators |
| 2021-06-27 14:49:26 | San Francisco Golden Gators | | Demoted | Roland Aldridge | Little Rock Fighting Farmers |
| 2021-06-27 14:49:12 | San Francisco Golden Gators | | Demoted | Scott Mendez | Little Rock Fighting Farmers |
| 2021-06-27 14:48:46 | Little Rock Fighting Farmers | | Promoted | Isaiah Anderson | San Francisco Golden Gators |
| 2021-06-26 11:41:40 | Indianapolis Tornadoes | Roberto Morse | Add/Drop | Elgin Espinoza | |