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| 2021-12-30 18:38:58 | Green Bay Miners | | Promoted | Joseph Forge | Baltimore Miners |
| 2021-12-30 18:38:30 | Baltimore Miners | | Demoted | Henry Knox | Green Bay Miners |
| 2021-12-30 18:29:10 | Cincinnati Skyliners | | Drop | Elton York | |
| 2021-12-30 18:28:10 | Cincinnati Skyliners | | Drop | Jesus Mitchell | |
| 2021-12-30 18:25:38 | Green Bay Miners | | Promoted | John Smith | Baltimore Miners |
| 2021-12-30 18:21:18 | Baltimore Miners | | Demoted | Isaiah Walton | Green Bay Miners |
| 2021-12-30 18:20:12 | Green Bay Miners | | Promoted | Jerome Jackson | Baltimore Miners |
| 2021-12-30 18:19:08 | Baltimore Miners | | Drop | Seth Essex | |
| 2021-12-30 17:49:10 | Pittsburgh Berserkers | | Promoted | Nicholas Schneider | Cleveland Weasels |
| 2021-12-30 17:42:34 | Santiago Sharks | | Promoted | Sonny Kincaid | San Diego Sabercats |
| 2021-12-30 17:36:04 | San Diego Sabercats | | Demoted | James Dillon | Santiago Sharks |
| 2021-12-30 17:34:58 | San Diego Sabercats | | Drop | Isaac Brown | |
| 2021-12-30 14:13:50 | Miami Macho Men | | Demoted | Dylan Lemire | Nashville Night Owls |
| 2021-12-30 13:18:54 | Toronto Huskies | | Promoted | Rudy Abeyta | Salt Lake City Night Hawks |
| 2021-12-30 13:06:34 | Milwaukee Sundancers | | Drop | Clifford Clark | |
| 2021-12-30 13:05:56 | Milwaukee Sundancers | | Drop | Sylvester Dixon | |
| 2021-12-30 12:49:52 | Milwaukee Sundancers | | Drop | Richard Verble | |
| 2021-12-30 12:48:08 | Milwaukee Sundancers | | Drop | Norberto Burgess | |
| 2021-12-30 12:42:14 | Milwaukee Sundancers | | Demoted | Jamarcus Buckles | Winnipeg Warriors |
| 2021-12-30 12:42:06 | Milwaukee Sundancers | | Demoted | Christopher Brooks | Winnipeg Warriors |
| 2021-12-30 12:26:28 | Milwaukee Sundancers | | Drop | Connor Frye | |
| 2021-12-30 12:22:20 | Las Vegas Dark Knights | | Drop | Richard Pope | |
| 2021-12-30 10:56:00 | Little Rock Fighting Farmers | | Promoted | CarlLee Hamilton | San Francisco Golden Gators |
| 2021-12-30 10:55:46 | San Francisco Golden Gators | | Demoted | Antonio Johnson | Little Rock Fighting Farmers |
| 2021-12-30 10:21:58 | San Francisco Golden Gators | | Demoted | Daniel Ramirez | Little Rock Fighting Farmers |