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| 2021-04-24 13:05:30 | Salt Lake City Night Hawks | | Demoted | Joshua Childress | Toronto Huskies |
| 2021-04-24 13:05:22 | Salt Lake City Night Hawks | | Demoted | Quinn Walker | Toronto Huskies |
| 2021-04-24 13:05:10 | Salt Lake City Night Hawks | | Demoted | Jacob Rivard | Toronto Huskies |
| 2021-04-24 12:13:42 | Atlanta Eels | | Demoted | Ross Watts | Tampa Runner-ups |
| 2021-04-24 11:04:00 | Houston Octopods | Sam Bushman | Acquired via trade | 1st round pick in season 30 | San Diego Sabercats |
| 2021-04-24 10:55:10 | Tampa Runner-ups | | Promoted | Robert Vance | Atlanta Eels |
| 2021-04-24 10:54:44 | Tampa Runner-ups | | Promoted | Colby Messer | Atlanta Eels |
| 2021-04-24 10:54:26 | Tampa Runner-ups | | Promoted | Bernie Kramer | Atlanta Eels |
| 2021-04-24 10:53:58 | Atlanta Eels | | Demoted | Dejuan Bohne | Tampa Runner-ups |
| 2021-04-24 10:53:40 | Atlanta Eels | | Demoted | Myles Cunningham | Tampa Runner-ups |
| 2021-04-24 10:30:00 | Charlotte Rangers | Barry Holland | Acquired via trade | 1st round pick in season 30 | New York Warriors |
| 2021-04-24 10:30:00 | Charlotte Rangers | Joshua Williams | Acquired via trade | 3rd round pick in season 30 | New York Warriors |
| 2021-04-24 10:30:00 | Charlotte Rangers | 2nd round pick in season 30 | Acquired via trade | | New York Warriors |
| 2021-04-24 10:30:00 | Charlotte Rangers | 2nd round pick in season 30 | Acquired via trade | | New York Warriors |
| 2021-04-24 06:48:22 | Louisville Colonels | | Demoted | Tyler Lamarre | Buffalo Bombers |
| 2021-04-22 21:00:00 | Seattle Cougars | 1st round pick in season 30 | Acquired via trade | 1st round pick in season 30 | St. Louis 5th Alarm |
| 2021-04-22 21:00:00 | Seattle Cougars | 3rd round pick in season 30 | Acquired via trade | | St. Louis 5th Alarm |
| 2021-04-22 20:56:00 | Dallas Hounds | 1st round pick in season 30 | Acquired via trade | Alexander Masten | Seattle Cougars |
| 2021-04-22 06:34:20 | Knoxville Wampus Cats | | Promoted | Jayson Basham | Las Vegas Dark Knights |
| 2021-04-21 08:24:00 | St. Louis 5th Alarm | Johnny Pippin | Acquired via trade | Adolph Cox | Las Vegas Dark Knights |
| 2021-04-21 08:24:00 | St. Louis 5th Alarm | 2nd round pick in season 30 | Acquired via trade | Horace Bartlett | Las Vegas Dark Knights |
| 2021-04-21 08:24:00 | St. Louis 5th Alarm | 3rd round pick in season 30 | Acquired via trade | | Las Vegas Dark Knights |
| 2021-04-21 08:22:00 | Salt Lake City Night Hawks | 1st round pick in season 30 | Acquired via trade | Brandon Lotz | Las Vegas Dark Knights |
| 2021-04-21 08:20:00 | Minneapolis Bricklayers | 1st round pick in season 31 | Acquired via trade | 1st round pick in season 30 | Indianapolis Tornadoes |
| 2021-04-21 08:20:00 | Minneapolis Bricklayers | 3rd round pick in season 31 | Acquired via trade | 3rd round pick in season 30 | Indianapolis Tornadoes |