| 2021-05-09 18:50:40 | San Francisco Golden Gators | | Demoted | Alec Black | Little Rock Fighting Farmers |
| 2021-05-09 18:47:36 | Little Rock Fighting Farmers | | Promoted | Alec Black | San Francisco Golden Gators |
| 2021-05-09 18:46:56 | San Francisco Golden Gators | | Demoted | CarlLee Hamilton | Little Rock Fighting Farmers |
| 2021-05-09 18:46:36 | Little Rock Fighting Farmers | | Promoted | K.C. Ludwig | San Francisco Golden Gators |
| 2021-05-09 18:46:16 | San Francisco Golden Gators | | Demoted | K.C. Ludwig | Little Rock Fighting Farmers |
| 2021-05-09 18:45:46 | Little Rock Fighting Farmers | | Promoted | Don Ostrowski | San Francisco Golden Gators |
| 2021-05-09 18:45:04 | San Francisco Golden Gators | | Drop | Duane Dunn | |
| 2021-05-09 15:04:56 | Charlotte Rangers | | Drop | Ricky Pearson | |
| 2021-05-09 15:04:12 | Charlotte Rangers | | Drop | Tony Foster | |
| 2021-05-09 14:51:20 | Cleveland Weasels | Ted Cureton | Add/Drop | | |
| 2021-05-09 14:50:50 | Cleveland Weasels | William Cosper | Add/Drop | | |
| 2021-05-09 13:45:22 | Miami Macho Men | Edward Dupree | Add/Drop | | |
| 2021-05-09 12:15:04 | Seattle Cougars | | Demoted | Michael Nash | Vancouver Mounties |
| 2021-05-09 11:58:00 | Las Vegas Dark Knights | Walter Henderson | Acquired via waivers | Herbert Trainor | Waiver |
| 2021-05-09 11:56:00 | Dallas Hounds | Samuel Kinder | Acquired via trade | Lamont Sanford | Seattle Cougars |
| 2021-05-09 11:00:28 | Philadelphia Assassins | | Demoted | Valentine Lovett | South Dakota Blackhawks |
| 2021-05-09 10:59:48 | South Dakota Blackhawks | | Promoted | Rodolfo Chu | Philadelphia Assassins |
| 2021-05-09 08:40:10 | Norfolk Wolves | | Promoted | Darrell Boggs | Dallas Hounds |
| 2021-05-08 18:04:46 | Detroit Gear Daddies | | Promoted | Andrew Erby | New Orleans Hurricanes |
| 2021-05-08 18:02:38 | New Orleans Hurricanes | | Demoted | Jaylin Torres | Detroit Gear Daddies |
| 2021-05-08 17:59:02 | New Orleans Hurricanes | | Drop | Scott Mendez | |
| 2021-05-08 17:51:02 | New Orleans Hurricanes | | Drop | Frank Alcorn | |
| 2021-05-08 16:01:00 | Mexico City Aztecs | | Promoted | Jeffrey Otoole | Denver Ferris Wheels |
| 2021-05-08 16:00:46 | Denver Ferris Wheels | | Demoted | Jorge Gividen | Mexico City Aztecs |
| 2021-05-08 14:16:00 | Sacramento Rainbow Trout | Miguel Lawson | Acquired via waivers | Walter Hopkins | Waiver |