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| 2021-04-30 04:33:36 | Miami Macho Men | | Demoted | Kyre Sanders | Nashville Night Owls |
| 2021-04-29 22:18:00 | San Diego Sabercats | Thomas Cox | Acquired via waivers | | Waiver |
| 2021-04-29 22:02:00 | Denver Ferris Wheels | Vance Hom | Acquired via trade | 2nd round pick in season 31 | St. Louis 5th Alarm |
| 2021-04-29 22:02:00 | Denver Ferris Wheels | Jeffrey Otoole | Acquired via trade | 3rd round pick in season 31 | St. Louis 5th Alarm |
| 2021-04-29 22:02:00 | Denver Ferris Wheels | Ricardo Mckeown | Acquired via trade | | St. Louis 5th Alarm |
| 2021-04-29 22:02:00 | Denver Ferris Wheels | 3rd round pick in season 31 | Acquired via trade | | St. Louis 5th Alarm |
| 2021-04-29 22:02:00 | Denver Ferris Wheels | Hayden Lantz | Acquired via trade | | St. Louis 5th Alarm |
| 2021-04-29 22:02:00 | Denver Ferris Wheels | David Fry | Acquired via trade | | St. Louis 5th Alarm |
| 2021-04-29 22:02:00 | Denver Ferris Wheels | Benny Ward | Acquired via trade | | St. Louis 5th Alarm |
| 2021-04-29 22:00:00 | Orlando Bombers | Cody Grabowski | Acquired via trade | 2nd round pick in season 31 | Salt Lake City Night Hawks |
| 2021-04-29 22:00:00 | Orlando Bombers | Hugh Wolf | Acquired via trade | | Salt Lake City Night Hawks |
| 2021-04-29 21:55:54 | Atlanta Eels | | Demoted | Coleman Bowen | Tampa Runner-ups |
| 2021-04-29 21:45:46 | Denver Ferris Wheels | | Drop | Buck Russell | |
| 2021-04-29 21:41:32 | Mexico City Aztecs | | Promoted | Jeffrey Otoole | Denver Ferris Wheels |
| 2021-04-29 21:39:38 | Denver Ferris Wheels | | Drop | Roger Nelson | |
| 2021-04-29 21:34:36 | Denver Ferris Wheels | | Drop | Benny Blanco | |
| 2021-04-29 21:30:48 | San Diego Sabercats | | Demoted | Jamarcus Buckles | Santiago Sharks |
| 2021-04-29 21:30:38 | San Diego Sabercats | | Demoted | Thomas Cox | Santiago Sharks |
| 2021-04-29 21:20:48 | Denver Ferris Wheels | | Drop | Hal Brooks | |
| 2021-04-29 21:20:06 | Denver Ferris Wheels | | Demoted | Jeffrey Otoole | Mexico City Aztecs |
| 2021-04-29 21:10:28 | Denver Ferris Wheels | | Demoted | Jason Alexander | Mexico City Aztecs |
| 2021-04-29 21:10:22 | Denver Ferris Wheels | | Demoted | Jorge Gividen | Mexico City Aztecs |
| 2021-04-29 21:07:22 | Mexico City Aztecs | | Promoted | Jason Alexander | Denver Ferris Wheels |
| 2021-04-29 21:07:16 | Mexico City Aztecs | | Promoted | Jorge Gividen | Denver Ferris Wheels |
| 2021-04-29 20:50:32 | Calgary Cougars | | Promoted | Roy Schiefelbein | San Antonio Brothas |