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| 2021-04-29 20:50:26 | Calgary Cougars | | Promoted | Larry Anderson | San Antonio Brothas |
| 2021-04-29 18:31:38 | Caracas Crocodiles | | Promoted | Winston Hoag | St. Louis 5th Alarm |
| 2021-04-29 15:48:24 | Denver Ferris Wheels | | Demoted | Jason Alexander | Mexico City Aztecs |
| 2021-04-29 15:48:20 | Denver Ferris Wheels | | Demoted | Jorge Gividen | Mexico City Aztecs |
| 2021-04-29 15:48:12 | Denver Ferris Wheels | | Demoted | Clarence Whaley | Mexico City Aztecs |
| 2021-04-29 10:06:00 | San Francisco Golden Gators | Roland Aldridge | Acquired via trade | 3rd round pick in season 31 | Dallas Hounds |
| 2021-04-29 10:06:00 | San Francisco Golden Gators | Alec Black | Acquired via trade | 3rd round pick in season 31 | Dallas Hounds |
| 2021-04-29 10:06:00 | San Francisco Golden Gators | Daron Gonsales | Acquired via trade | | Dallas Hounds |
| 2021-04-29 10:06:00 | San Francisco Golden Gators | Uriel Jones | Acquired via trade | | Dallas Hounds |
| 2021-04-29 10:06:00 | San Francisco Golden Gators | Albert Reeves | Acquired via trade | | Dallas Hounds |
| 2021-04-29 10:06:00 | San Francisco Golden Gators | Don Ostrowski | Acquired via trade | | Dallas Hounds |
| 2021-04-29 10:04:00 | Salt Lake City Night Hawks | 3rd round pick in season 32 | Acquired via trade | Michael Dally | Philadelphia Assassins |
| 2021-04-29 10:02:00 | Salt Lake City Night Hawks | 3rd round pick in season 32 | Acquired via trade | Gary Galan | Boston Bannerman |
| 2021-04-29 10:00:00 | San Diego Sabercats | Jamarcus Buckles | Acquired via waivers | | Waiver |
| 2021-04-29 05:40:46 | Cincinnati Skyliners | | Demoted | Marshall Gilmore | Sao Paulo Jackalopes |
| 2021-04-29 05:40:26 | Cincinnati Skyliners | | Demoted | Rubin Elwood | Sao Paulo Jackalopes |
| 2021-04-29 05:39:20 | Cincinnati Skyliners | | Drop | Tyron Jordan | |
| 2021-04-29 05:38:44 | Cincinnati Skyliners | | Drop | Clayton Curry | |
| 2021-04-29 05:28:10 | Little Rock Fighting Farmers | | Promoted | Garrett Nelson | San Francisco Golden Gators |
| 2021-04-29 04:58:40 | Little Rock Fighting Farmers | | Promoted | K.C. Ludwig | San Francisco Golden Gators |
| 2021-04-29 04:58:20 | San Francisco Golden Gators | | Demoted | Victor Rodrigues | Little Rock Fighting Farmers |
| 2021-04-29 04:42:38 | San Francisco Golden Gators | | Drop | Dean Kim | |
| 2021-04-29 04:41:32 | San Francisco Golden Gators | | Drop | Francis Brown | |
| 2021-04-29 04:38:34 | San Francisco Golden Gators | | Drop | David Poling | |
| 2021-04-28 22:45:42 | Portland Hipsters | | Demoted | Phillip Luck | Montreal Ice Cats |