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| 2021-04-21 08:24:00 | St. Louis 5th Alarm | Johnny Pippin | Acquired via trade | Adolph Cox | Las Vegas Dark Knights |
| 2021-04-21 08:24:00 | St. Louis 5th Alarm | 2nd round pick in season 30 | Acquired via trade | Horace Bartlett | Las Vegas Dark Knights |
| 2021-04-21 08:24:00 | St. Louis 5th Alarm | 3rd round pick in season 30 | Acquired via trade | | Las Vegas Dark Knights |
| 2021-04-21 08:22:00 | Salt Lake City Night Hawks | 1st round pick in season 30 | Acquired via trade | Brandon Lotz | Las Vegas Dark Knights |
| 2021-04-21 08:20:00 | Minneapolis Bricklayers | 1st round pick in season 31 | Acquired via trade | 1st round pick in season 30 | Indianapolis Tornadoes |
| 2021-04-21 08:20:00 | Minneapolis Bricklayers | 3rd round pick in season 31 | Acquired via trade | 3rd round pick in season 30 | Indianapolis Tornadoes |
| 2021-04-21 08:18:00 | Dallas Hounds | Alexander Masten | Acquired via trade | 1st round pick in season 30 | Atlanta Eels |
| 2021-04-20 08:37:20 | Minneapolis Bricklayers | | Demoted | Mark Penny | Santo Domingo Lazy Dogs |
| 2021-04-18 13:02:32 | Santo Domingo Lazy Dogs | | Promoted | Mark Penny | Minneapolis Bricklayers |
| 2021-04-13 10:03:42 | New Orleans Hurricanes | | Demoted | Edward Mcelrath | Detroit Gear Daddies |
| 2021-04-13 10:02:38 | Detroit Gear Daddies | | Promoted | Alton Cage | New Orleans Hurricanes |
| 2021-04-13 02:58:28 | Louisville Colonels | Issac Oconnell | Add/Drop | | |
| 2021-04-12 23:22:54 | Buffalo Bombers | | Promoted | Peter Crites | Louisville Colonels |
| 2021-04-12 23:22:32 | Buffalo Bombers | | Promoted | Eugene Fitzpatrick | Louisville Colonels |
| 2021-04-12 23:22:00 | Buffalo Bombers | | Promoted | Claude Rodriguez | Louisville Colonels |
| 2021-04-11 13:41:14 | Indianapolis Tornadoes | Dante Joseph | Add/Drop | | |
| 2021-04-10 12:10:20 | New Orleans Hurricanes | Andrew Erby | Add/Drop | Howard McDonald | |
| 2021-04-09 10:20:50 | Indianapolis Tornadoes | | Drop | Todd Stern | |
| 2021-04-09 10:13:56 | Buenos Aires Eagles | | Promoted | Lowell Nielsen | Indianapolis Tornadoes |
| 2021-04-08 22:31:24 | Mexico City Aztecs | | Promoted | Victor Rodrigues | Denver Ferris Wheels |
| 2021-04-08 22:30:14 | Denver Ferris Wheels | | Demoted | David Bowersox | Mexico City Aztecs |
| 2021-04-05 21:45:44 | Minneapolis Bricklayers | | Demoted | Roland Leonard | Santo Domingo Lazy Dogs |
| 2021-04-05 21:35:16 | Santo Domingo Lazy Dogs | | Promoted | Warren Rickard | Minneapolis Bricklayers |
| 2021-04-02 15:32:52 | New Orleans Hurricanes | | Demoted | Alton Cage | Detroit Gear Daddies |
| 2021-04-02 15:32:20 | Detroit Gear Daddies | | Promoted | Edward Mcelrath | New Orleans Hurricanes |