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| 2021-01-07 21:49:18 | Baltimore Miners | | Drop | Clifford Little | |
| 2021-01-07 18:23:38 | San Diego Sabercats | | Drop | Louie Sprinkle | |
| 2021-01-07 18:22:12 | San Diego Sabercats | | Drop | Derick Bernal | |
| 2021-01-07 18:09:44 | Louisville Colonels | | Demoted | Claude Rodriguez | Buffalo Bombers |
| 2021-01-07 15:50:00 | New York Warriors | Antonio Rogers | Acquired via trade | 2nd round pick in season 31 | Salt Lake City Night Hawks |
| 2021-01-07 15:50:00 | New York Warriors | 3rd round pick in season 31 | Acquired via trade | 2nd round pick in season 31 | Salt Lake City Night Hawks |
| 2021-01-07 15:30:00 | Baltimore Miners | Mason Graziano | Acquired via trade | 3rd round pick in season 30 | Salt Lake City Night Hawks |
| 2021-01-07 15:30:00 | Baltimore Miners | Freddie Sheets | Acquired via trade | | Salt Lake City Night Hawks |
| 2021-01-07 15:30:00 | Baltimore Miners | Buck Russell | Acquired via trade | | Salt Lake City Night Hawks |
| 2021-01-07 15:20:00 | Vancouver Mounties | | Promoted | Gregory Dowling | Seattle Cougars |
| 2021-01-07 15:20:00 | San Diego Sabercats | Patrick Overton | Acquired via waivers | | Waiver |
| 2021-01-07 15:17:16 | Seattle Cougars | | Demoted | Bailey Oakley | Vancouver Mounties |
| 2021-01-07 15:12:00 | Seattle Cougars | Theo Stanton | Acquired via trade | 2nd round pick in season 31 | New York Warriors |
| 2021-01-07 15:12:00 | Seattle Cougars | Duane Dunn | Acquired via trade | | New York Warriors |
| 2021-01-07 15:10:00 | Louisville Colonels | Eugene Fitzpatrick | Acquired via trade | 2nd round pick in season 31 | Salt Lake City Night Hawks |
| 2021-01-07 15:10:00 | Louisville Colonels | Kirby Ross | Acquired via trade | | Salt Lake City Night Hawks |
| 2021-01-07 14:55:22 | Seattle Cougars | | Drop | Milt Jackson | |
| 2021-01-07 14:37:26 | Seattle Cougars | | Drop | Marquez Sparkman | |
| 2021-01-07 14:18:32 | San Diego Sabercats | | Drop | Patrick Overton | |
| 2021-01-06 21:43:20 | Miami Macho Men | | Drop | Christian Grove | |
| 2021-01-06 20:11:52 | St. Louis 5th Alarm | | Demoted | Winston Hoag | Caracas Crocodiles |
| 2021-01-06 20:11:48 | St. Louis 5th Alarm | | Demoted | Jeffrey Otoole | Caracas Crocodiles |
| 2021-01-06 17:54:24 | Milwaukee Sundancers | | Drop | Ira Medrano | |
| 2021-01-06 17:47:10 | Milwaukee Sundancers | | Drop | Samuel Saum | |
| 2021-01-06 17:46:12 | Milwaukee Sundancers | | Drop | Ricky Hill | |