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| 2021-08-21 14:38:44 | Boston Bannerman | | Demoted | Harold Lewis | Birmingham Venom |
| 2021-08-21 14:30:14 | Louisville Colonels | | Demoted | Colby Bowen | Buffalo Bombers |
| 2021-08-21 14:30:04 | Louisville Colonels | | Demoted | Brian Thomas | Buffalo Bombers |
| 2021-08-21 14:29:50 | Louisville Colonels | | Demoted | Ethan Derose | Buffalo Bombers |
| 2021-08-21 13:42:36 | Atlanta Eels | | Demoted | Rene Keller | Tampa Runner-ups |
| 2021-08-21 12:43:42 | Atlanta Eels | | Demoted | Justin McInnis | Tampa Runner-ups |
| 2021-08-21 12:08:36 | Indianapolis Tornadoes | | Demoted | Derrick Gonzalez | Buenos Aires Eagles |
| 2021-08-21 12:07:50 | Orlando Bombers | | Demoted | Alex Strickland | Ottawa Mt. Hawks |
| 2021-08-21 10:35:44 | Atlanta Eels | | Demoted | Samuel Fowler | Tampa Runner-ups |
| 2021-08-21 10:28:00 | New York Warriors | Guy Fink | Acquired via trade | Isaac Brown | San Diego Sabercats |
| 2021-08-21 10:28:00 | New York Warriors | Stanley Wright | Acquired via trade | | San Diego Sabercats |
| 2021-08-21 10:20:00 | Seattle Cougars | 2nd round pick in season 31 | Acquired via trade | 2nd round pick in season 32 | St. Louis 5th Alarm |
| 2021-08-21 10:20:00 | Seattle Cougars | 3rd round pick in season 31 | Acquired via trade | | St. Louis 5th Alarm |
| 2021-08-21 10:14:00 | St. Louis 5th Alarm | 1st round pick in season 31 | Acquired via trade | Elmer Robinson | San Diego Sabercats |
| 2021-08-21 10:10:00 | Louisville Colonels | 2nd round pick in season 31 | Acquired via trade | 2nd round pick in season 33 | New York Warriors |
| 2021-08-21 10:10:00 | Louisville Colonels | 2nd round pick in season 31 | Acquired via trade | | New York Warriors |
| 2021-08-21 10:10:00 | Louisville Colonels | 3rd round pick in season 31 | Acquired via trade | | New York Warriors |
| 2021-08-21 09:51:20 | Atlanta Eels | | Drop | Brady Lasley | |
| 2021-08-21 05:56:54 | Knoxville Wampus Cats | | Promoted | James Vieira | Las Vegas Dark Knights |
| 2021-08-21 05:56:08 | Knoxville Wampus Cats | | Promoted | Adolph Cox | Las Vegas Dark Knights |
| 2021-08-20 16:36:00 | New York Warriors | Christian Mallard | Add/Drop | Patrick Magee | |
| 2021-08-20 16:31:48 | New York Warriors | Patrick Magee | Add/Drop | | |
| 2021-08-20 16:25:48 | New York Warriors | Daniel Dukes | Add/Drop | | |
| 2021-08-20 14:42:38 | New York Warriors | | Demoted | Joseph Jackson | Hartford Hebrew Hammers |
| 2021-08-20 10:50:00 | San Diego Sabercats | Jacob Dolan | Acquired via trade | Glen Jackson | Dallas Hounds |