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| 2021-08-20 10:50:00 | San Diego Sabercats | Austin Wyatt | Acquired via trade | 1st round pick in season 31 | Dallas Hounds |
| 2021-08-20 10:50:00 | San Diego Sabercats | 2nd round pick in season 32 | Acquired via trade | | Dallas Hounds |
| 2021-08-20 10:43:42 | San Diego Sabercats | | Demoted | Jacob Dolan | Santiago Sharks |
| 2021-08-20 10:26:00 | Boston Bannerman | Anthony Green | Acquired via trade | 1st round pick in season 32 | New York Warriors |
| 2021-08-20 10:26:00 | Boston Bannerman | Brian Parris | Acquired via trade | Jacob Williams | New York Warriors |
| 2021-08-20 10:26:00 | Boston Bannerman | Jean Quinn | Acquired via trade | 3rd round pick in season 33 | New York Warriors |
| 2021-08-20 10:26:00 | Boston Bannerman | 1st round pick in season 31 | Acquired via trade | | New York Warriors |
| 2021-08-20 09:39:52 | Boston Bannerman | | Demoted | Maximus Harris | Birmingham Venom |
| 2021-08-20 09:39:40 | Boston Bannerman | | Demoted | Anthony Green | Birmingham Venom |
| 2021-08-20 08:55:34 | Norfolk Wolves | | Promoted | Brandon Chapman | Dallas Hounds |
| 2021-08-19 14:53:28 | Sao Paulo Jackalopes | | Promoted | Jonathan Ott | Cincinnati Skyliners |
| 2021-08-19 14:50:26 | Cincinnati Skyliners | | Demoted | Kaden Sanders | Sao Paulo Jackalopes |
| 2021-08-19 13:57:22 | New York Warriors | | Demoted | Jacob Larkins | Hartford Hebrew Hammers |
| 2021-08-19 13:56:52 | Hartford Hebrew Hammers | | Promoted | Karl Coe | New York Warriors |
| 2021-08-19 13:54:00 | Hartford Hebrew Hammers | | Promoted | Jaymes Stewart | New York Warriors |
| 2021-08-19 12:19:00 | Baltimore Miners | Daron Gonsales | Add/Drop | Freddie Sheets | |
| 2021-08-18 23:52:18 | Cincinnati Skyliners | | Demoted | Ryan Nellis | Sao Paulo Jackalopes |
| 2021-08-18 23:45:22 | Sao Paulo Jackalopes | | Promoted | Dion Burr | Cincinnati Skyliners |
| 2021-08-18 23:45:06 | Cincinnati Skyliners | | Demoted | Deon Burke | Sao Paulo Jackalopes |
| 2021-08-18 23:42:08 | Sao Paulo Jackalopes | | Promoted | Zachary Sledge | Cincinnati Skyliners |
| 2021-08-18 23:41:54 | Sao Paulo Jackalopes | | Promoted | Ken Skelley | Cincinnati Skyliners |
| 2021-08-18 23:40:28 | Cincinnati Skyliners | | Demoted | Darius McVey | Sao Paulo Jackalopes |
| 2021-08-17 19:36:00 | Los Angeles Cacti | Patrick Edelen | Acquired via trade | Philip Cruz | Salt Lake City Night Hawks |
| 2021-08-17 19:36:00 | Los Angeles Cacti | 2nd round pick in season 31 | Acquired via trade | | Salt Lake City Night Hawks |
| 2021-08-17 19:36:00 | Los Angeles Cacti | 2nd round pick in season 31 | Acquired via trade | | Salt Lake City Night Hawks |