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| 2021-04-30 13:20:28 | San Francisco Golden Gators | | Drop | Carson Boling | |
| 2021-04-30 13:20:08 | San Francisco Golden Gators | | Drop | Gerald Campbell | |
| 2021-04-30 13:19:32 | San Francisco Golden Gators | | Drop | Bruce Sutphin | |
| 2021-04-30 13:15:58 | Philadelphia Assassins | | Demoted | Jason Taylor | South Dakota Blackhawks |
| 2021-04-30 13:14:58 | South Dakota Blackhawks | | Promoted | David Anderson | Philadelphia Assassins |
| 2021-04-30 08:43:24 | Boston Bannerman | | Demoted | Gary Galan | Birmingham Venom |
| 2021-04-30 04:35:16 | Miami Macho Men | | Drop | Patrick Overton | |
| 2021-04-30 04:33:36 | Miami Macho Men | | Demoted | Kyre Sanders | Nashville Night Owls |
| 2021-04-29 22:18:00 | San Diego Sabercats | Thomas Cox | Acquired via waivers | | Waiver |
| 2021-04-29 22:02:00 | Denver Ferris Wheels | Vance Hom | Acquired via trade | 2nd round pick in season 31 | St. Louis 5th Alarm |
| 2021-04-29 22:02:00 | Denver Ferris Wheels | Jeffrey Otoole | Acquired via trade | 3rd round pick in season 31 | St. Louis 5th Alarm |
| 2021-04-29 22:02:00 | Denver Ferris Wheels | Ricardo Mckeown | Acquired via trade | | St. Louis 5th Alarm |
| 2021-04-29 22:02:00 | Denver Ferris Wheels | 3rd round pick in season 31 | Acquired via trade | | St. Louis 5th Alarm |
| 2021-04-29 22:02:00 | Denver Ferris Wheels | Hayden Lantz | Acquired via trade | | St. Louis 5th Alarm |
| 2021-04-29 22:02:00 | Denver Ferris Wheels | David Fry | Acquired via trade | | St. Louis 5th Alarm |
| 2021-04-29 22:02:00 | Denver Ferris Wheels | Benny Ward | Acquired via trade | | St. Louis 5th Alarm |
| 2021-04-29 22:00:00 | Orlando Bombers | Cody Grabowski | Acquired via trade | 2nd round pick in season 31 | Salt Lake City Night Hawks |
| 2021-04-29 22:00:00 | Orlando Bombers | Hugh Wolf | Acquired via trade | | Salt Lake City Night Hawks |
| 2021-04-29 21:55:54 | Atlanta Eels | | Demoted | Coleman Bowen | Tampa Runner-ups |
| 2021-04-29 21:45:46 | Denver Ferris Wheels | | Drop | Buck Russell | |
| 2021-04-29 21:41:32 | Mexico City Aztecs | | Promoted | Jeffrey Otoole | Denver Ferris Wheels |
| 2021-04-29 21:39:38 | Denver Ferris Wheels | | Drop | Roger Nelson | |
| 2021-04-29 21:34:36 | Denver Ferris Wheels | | Drop | Benny Blanco | |
| 2021-04-29 21:30:48 | San Diego Sabercats | | Demoted | Jamarcus Buckles | Santiago Sharks |
| 2021-04-29 21:30:38 | San Diego Sabercats | | Demoted | Thomas Cox | Santiago Sharks |