|
| 2022-05-04 08:18:00 | Houston Octopods | Isaiah Anderson | Acquired via trade | David Anderson | Waiver |
| 2022-05-04 08:16:00 | Dallas Hounds | Austin Davidson | Acquired via trade | 2nd round pick in season 34 | Indianapolis Tornadoes |
| 2022-05-04 08:16:00 | Dallas Hounds | Murray Smith | Acquired via trade | | Indianapolis Tornadoes |
| 2022-05-04 08:15:38 | New Orleans Hurricanes | | Drop | David Kimble | |
| 2022-05-04 08:14:00 | Seattle Cougars | 3rd round pick in season 34 | Acquired via trade | 3rd round pick in season 34 | St. Louis 5th Alarm |
| 2022-05-04 08:14:00 | Seattle Cougars | Seven Lemay | Acquired via trade | | St. Louis 5th Alarm |
| 2022-05-04 08:12:00 | Kansas City Wildcats | Dakota Freeman | Acquired via trade | 3rd round pick in season 34 | San Francisco Golden Gators |
| 2022-05-04 08:12:00 | Kansas City Wildcats | Daniel Ramirez | Acquired via trade | | San Francisco Golden Gators |
| 2022-05-04 08:12:00 | Kansas City Wildcats | 3rd round pick in season 34 | Acquired via trade | | San Francisco Golden Gators |
| 2022-05-04 08:00:06 | New Orleans Hurricanes | | Demoted | David Kimble | Detroit Gear Daddies |
| 2022-05-04 04:57:12 | Memphis Express | | Drop | Daniel Charlot | |
| 2022-05-04 04:53:26 | Memphis Express | | Drop | Lucien Dickerson | |
| 2022-05-03 23:51:08 | Denver Ferris Wheels | | Drop | Raul Lopez | |
| 2022-05-03 21:40:34 | Las Vegas Dark Knights | | Drop | Wyatt Holloway | |
| 2022-05-03 20:35:24 | Seattle Cougars | | Drop | Johnny Pippin | |
| 2022-05-03 19:40:24 | Memphis Express | | Drop | Stanley Schwager | |
| 2022-05-03 18:49:40 | San Francisco Golden Gators | | Demoted | Richard Walker | Little Rock Fighting Farmers |
| 2022-05-03 17:45:08 | San Antonio Brothas | | Drop | Walter Henderson | |
| 2022-05-03 17:44:38 | San Antonio Brothas | | Drop | Kareem Robinson | |
| 2022-05-03 17:28:48 | Rio de Janeiro Red Storm | | Promoted | Tremayne Duenas | Charlotte Rangers |
| 2022-05-03 17:15:54 | Charlotte Rangers | | Drop | George Moffett | |
| 2022-05-03 17:15:28 | Charlotte Rangers | | Drop | Larry Reichert | |
| 2022-05-03 17:14:12 | Rio de Janeiro Red Storm | | Promoted | Connor Kahl | Charlotte Rangers |
| 2022-05-03 17:13:46 | Rio de Janeiro Red Storm | | Promoted | Sean Naughton | Charlotte Rangers |
| 2022-05-03 16:49:00 | Charlotte Rangers | | Demoted | Timothy Lindsey | Rio de Janeiro Red Storm |