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| 2022-04-23 15:44:06 | Dallas Hounds | | Demoted | Kobee Roach | Norfolk Wolves |
| 2022-04-23 15:43:46 | Atlanta Eels | | Demoted | Anton Owens | Tampa Runner-ups |
| 2022-04-23 15:43:38 | Dallas Hounds | | Demoted | Ian Bonilla | Norfolk Wolves |
| 2022-04-23 15:43:28 | Atlanta Eels | | Demoted | James Turner | Tampa Runner-ups |
| 2022-04-23 15:43:12 | Atlanta Eels | | Demoted | Jordan Dagostino | Tampa Runner-ups |
| 2022-04-23 15:30:26 | San Antonio Brothas | | Demoted | Jeremiah Withers | Calgary Cougars |
| 2022-04-23 15:30:22 | San Antonio Brothas | | Demoted | Fernando Ruiz | Calgary Cougars |
| 2022-04-23 15:25:32 | Houston Octopods | | Demoted | William McClary | Syracuse River Rats |
| 2022-04-23 15:25:26 | Houston Octopods | | Demoted | Colton Bragg | Syracuse River Rats |
| 2022-04-23 15:13:28 | St. Louis 5th Alarm | | Demoted | Dennis Annis | Caracas Crocodiles |
| 2022-04-23 15:13:22 | St. Louis 5th Alarm | | Demoted | Alexander Mills | Caracas Crocodiles |
| 2022-04-23 15:13:18 | St. Louis 5th Alarm | | Demoted | Joseph McDermott | Caracas Crocodiles |
| 2022-04-23 15:10:00 | Miami Macho Men | 2nd round pick in season 34 | Acquired via trade | 2nd round pick in season 33 | New York Warriors |
| 2022-04-23 15:10:00 | Miami Macho Men | 3rd round pick in season 34 | Acquired via trade | | New York Warriors |
| 2022-04-23 15:02:40 | Indianapolis Tornadoes | | Demoted | Emmanuel Ray | Buenos Aires Eagles |
| 2022-04-23 15:01:44 | Portland Hipsters | | Demoted | Joshua Bailey | Montreal Ice Cats |
| 2022-04-23 15:01:30 | Portland Hipsters | | Demoted | Alex Kirksey | Montreal Ice Cats |
| 2022-04-23 15:01:18 | Portland Hipsters | | Demoted | Shawn Kirkland | Montreal Ice Cats |
| 2022-04-23 15:00:58 | Montreal Ice Cats | | Promoted | Hunter Gardner | Portland Hipsters |
| 2022-04-23 15:00:00 | Philadelphia Assassins | 1st round pick in season 33 | Acquired via trade | 1st round pick in season 33 | Memphis Express |
| 2022-04-23 15:00:00 | Philadelphia Assassins | 1st round pick in season 34 | Acquired via trade | | Memphis Express |
| 2022-04-23 15:00:00 | Philadelphia Assassins | 1st round pick in season 33 | Acquired via trade | 1st round pick in season 33 | Indianapolis Tornadoes |
| 2022-04-23 15:00:00 | Philadelphia Assassins | 2nd round pick in season 33 | Acquired via trade | | Indianapolis Tornadoes |
| 2022-04-23 14:53:06 | Salt Lake City Night Hawks | | Demoted | Noah Riley | Toronto Huskies |
| 2022-04-23 14:53:00 | Salt Lake City Night Hawks | | Demoted | Gage Cunningham | Toronto Huskies |