|
| 2022-09-09 19:18:47 | Miami Macho Men | Gary Mitchem | Acquired via waivers | | Waiver |
| 2022-09-09 19:07:39 | San Francisco Golden Gators | Miguel Burleson | Acquired via trade | Gary Galan | Houston Octopods |
| 2022-09-09 19:07:39 | San Francisco Golden Gators | | Acquired via trade | Hunter Thomas | Houston Octopods |
| 2022-09-09 19:07:39 | San Francisco Golden Gators | | Acquired via trade | 2nd round pick in season 35 | Houston Octopods |
| 2022-09-09 19:07:39 | San Francisco Golden Gators | | Acquired via trade | 2nd round pick in season 35 | Houston Octopods |
| 2022-09-09 00:00:00 | Las Vegas Dark Knights | | Demoted | Joshua Childress | Knoxville Wampus Cats |
| 2022-09-09 00:00:00 | Las Vegas Dark Knights | | Drop | Seth Riddle | |
| 2022-09-09 00:00:00 | Kansas City Wildcats | | Drop | Nicholas Lawrence | |
| 2022-09-09 00:00:00 | Los Angeles Cacti | Joel Nobles | Add/Drop | | |
| 2022-09-09 00:00:00 | Los Angeles Cacti | | Demoted | Chandler Izzi | Quebec Buzz |
| 2022-09-09 00:00:00 | Los Angeles Cacti | Chandler Izzi | Add/Drop | Jeffrey Mitchell Jr. | |
| 2022-09-09 00:00:00 | San Diego Sabercats | Dustin Williams | Add/Drop | Sonny Kincaid | |
| 2022-09-09 00:00:00 | Los Angeles Cacti | Billy Harris | Add/Drop | Arnold Sapp | |
| 2022-09-09 00:00:00 | Los Angeles Cacti | Tyron Chan | Add/Drop | Erasmo Griffin | |
| 2022-09-09 00:00:00 | Orlando Bombers | | Drop | Wayne Salas | |
| 2022-09-09 00:00:00 | Seattle Cougars | Ronald Shelton | Add/Drop | | |
| 2022-09-08 19:54:17 | Kansas City Wildcats | Cameron Williams | Acquired via waivers | | Waiver |
| 2022-09-08 19:50:02 | Orlando Bombers | Carl Larue | Acquired via waivers | | Waiver |
| 2022-09-08 19:50:02 | Denver Ferris Wheels | Peter Fowler | Acquired via waivers | | Waiver |
| 2022-09-08 00:00:00 | San Diego Sabercats | | Demoted | Sonny Kincaid | Santiago Sharks |
| 2022-09-08 00:00:00 | Santiago Sharks | | Promoted | Sonny Kincaid | San Diego Sabercats |
| 2022-09-08 00:00:00 | San Diego Sabercats | | Demoted | Tyler Wright | Santiago Sharks |
| 2022-09-08 00:00:00 | San Diego Sabercats | Tyler Wright | Add/Drop | Elijah Curtis | |
| 2022-09-08 00:00:00 | Mexico City Aztecs | | Promoted | Jimmy Ham | Denver Ferris Wheels |
| 2022-09-08 00:00:00 | Denver Ferris Wheels | | Demoted | Ricardo James | Mexico City Aztecs |