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| 2022-09-05 00:00:00 | San Francisco Golden Gators | | Demoted | Fernando Boudreaux | Little Rock Fighting Farmers |
| 2022-09-05 00:00:00 | San Francisco Golden Gators | | Drop | Tyler Wright | |
| 2022-09-05 00:00:00 | San Francisco Golden Gators | | Drop | Harry Haley | |
| 2022-09-05 00:00:00 | San Francisco Golden Gators | | Drop | Carl Larue | |
| 2022-09-05 00:00:00 | Cincinnati Skyliners | Marcos Harrell | Add/Drop | Noah Sims | |
| 2022-09-05 00:00:00 | Hartford Hebrew Hammers | | Promoted | Joshua Langham | New York Warriors |
| 2022-09-05 00:00:00 | New York Warriors | | Demoted | Jonathan Woods | Hartford Hebrew Hammers |
| 2022-09-05 00:00:00 | Hartford Hebrew Hammers | | Promoted | Jonathan Woods | New York Warriors |
| 2022-09-05 00:00:00 | Hartford Hebrew Hammers | | Promoted | Jack Merritt | New York Warriors |
| 2022-09-05 00:00:00 | New Orleans Hurricanes | | Drop | Jerome Hancock | |
| 2022-09-05 00:00:00 | New Orleans Hurricanes | | Drop | Peter Fowler | |
| 2022-09-05 00:00:00 | St. Louis 5th Alarm | | Demoted | Aaren Hintz | Caracas Crocodiles |
| 2022-09-05 00:00:00 | St. Louis 5th Alarm | | Drop | Cameron Williams | |
| 2022-09-05 00:00:00 | Seattle Cougars | | Drop | Brent Robertson | |
| 2022-09-05 00:00:00 | Seattle Cougars | | Drop | Ronald Shelton | |
| 2022-09-04 16:40:38 | San Diego Sabercats | Antonio Rogers | Acquired via trade | 2nd round pick in season 36 | Salt Lake City Night Hawks |
| 2022-09-04 00:00:00 | Cleveland Weasels | | Drop | Jairo Byington | |
| 2022-09-04 00:00:00 | Cleveland Weasels | | Drop | Tristan Arnold | |
| 2022-09-04 00:00:00 | Denver Ferris Wheels | | Demoted | Silas Thomas | Mexico City Aztecs |
| 2022-09-04 00:00:00 | Denver Ferris Wheels | | Demoted | Jimmy Ham | Mexico City Aztecs |
| 2022-09-04 00:00:00 | Mexico City Aztecs | | Promoted | Ricardo James | Denver Ferris Wheels |
| 2022-09-04 00:00:00 | Mexico City Aztecs | | Promoted | Juan Goodwin | Denver Ferris Wheels |
| 2022-09-04 00:00:00 | Denver Ferris Wheels | | Drop | Joel Nobles | |
| 2022-09-04 00:00:00 | Denver Ferris Wheels | | Drop | Nathan Love | |
| 2022-09-04 00:00:00 | Denver Ferris Wheels | | Drop | Xavier Ralston | |