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| 2025-04-17 00:00:00 | Cleveland Weasels | | Demoted | Declan Black | Pittsburgh Berserkers |
| 2025-04-17 00:00:00 | San Francisco Golden Gators | | Demoted | Conner Paden | Little Rock Fighting Farmers |
| 2025-04-16 20:24:39 | Dallas Hounds | 2nd round pick in season 43 | Acquired via trade | 1st round pick in season 43 | New Orleans Hurricanes |
| 2025-04-16 20:24:39 | Dallas Hounds | Joseph McDermott | Acquired via trade | Jacob Jones | New Orleans Hurricanes |
| 2025-04-16 20:24:39 | Dallas Hounds | Jackson McNeil | Acquired via trade | | New Orleans Hurricanes |
| 2025-04-16 20:12:30 | San Francisco Golden Gators | John Smith | Acquired via trade | Damon Rodriguez | Dallas Hounds |
| 2025-04-16 20:12:30 | San Francisco Golden Gators | Joseph Forge | Acquired via trade | 2nd round pick in season 43 | Dallas Hounds |
| 2025-04-16 00:00:00 | Detroit Gear Daddies | | Promoted | Marcus Handie | New Orleans Hurricanes |
| 2025-04-16 00:00:00 | New Orleans Hurricanes | | Demoted | Jacob Jones | Detroit Gear Daddies |
| 2025-04-16 00:00:00 | New Orleans Hurricanes | | Demoted | Zachary Roebuck | Detroit Gear Daddies |
| 2025-04-16 00:00:00 | New Orleans Hurricanes | | Demoted | Jacob McCaskill | Detroit Gear Daddies |
| 2025-04-16 00:00:00 | Phoenix Kangaroos | | Demoted | Jared Dickinson | San Juan Devils |
| 2025-04-16 00:00:00 | Phoenix Kangaroos | | Demoted | Timothy Ward | San Juan Devils |
| 2025-04-16 00:00:00 | Los Angeles Cacti | | Demoted | Christopher Sexton | Quebec Buzz |
| 2025-04-16 00:00:00 | Buenos Aires Eagles | | Promoted | Javin Hill | Indianapolis Tornadoes |
| 2025-04-16 00:00:00 | San Antonio Brothas | | Drop | Louis Moore | |
| 2025-04-16 00:00:00 | San Antonio Brothas | | Drop | Harry Haley | |
| 2025-04-16 00:00:00 | San Antonio Brothas | | Drop | Seth Talbert | |
| 2025-04-16 00:00:00 | Las Vegas Dark Knights | Logan Wilkins | Add/Drop | | |
| 2025-04-16 00:00:00 | Orlando Bombers | | Demoted | Richard Rice | Ottawa Mt. Hawks |
| 2025-04-16 00:00:00 | Ottawa Mt. Hawks | | Promoted | Cole Knouse | Orlando Bombers |
| 2025-04-16 00:00:00 | Orlando Bombers | | Demoted | Reid Hardin | Ottawa Mt. Hawks |
| 2025-04-16 00:00:00 | Orlando Bombers | | Demoted | William Culbert | Ottawa Mt. Hawks |
| 2025-04-16 00:00:00 | Philadelphia Assassins | | Drop | Pedro Rice | |
| 2025-04-16 00:00:00 | Atlanta Eels | | Demoted | Daniel Haynes | Tampa Runner-ups |