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| 2022-05-06 04:03:20 | Milwaukee Sundancers | | Drop | Felipe Easley | |
| 2022-05-06 04:01:58 | Milwaukee Sundancers | | Drop | Clayton Vanhorn | |
| 2022-05-06 03:25:52 | Louisville Colonels | | Drop | Kirby Ross | |
| 2022-05-06 03:24:34 | Louisville Colonels | | Drop | Greg Jobe | |
| 2022-05-06 03:00:00 | Denver Ferris Wheels | Glenn Brown | Acquired via waivers | Stephen Decker | Waiver |
| 2022-05-06 03:00:00 | Miami Macho Men | Clifford Clark | Acquired via waivers | | Waiver |
| 2022-05-06 03:00:00 | Kansas City Wildcats | Joshua Carpenter | Acquired via waivers | | Waiver |
| 2022-05-06 03:00:00 | Philadelphia Assassins | Earl Ferrell | Acquired via waivers | Thomas Abrams | Waiver |
| 2022-05-06 02:43:44 | Sacramento Rainbow Trout | | Drop | Kenny Ryan | |
| 2022-05-06 02:37:00 | Sacramento Rainbow Trout | | Drop | Edmund Peyton | |
| 2022-05-06 02:28:36 | Sacramento Rainbow Trout | | Demoted | Zachary Senecal | Edmonton SilverShoes |
| 2022-05-06 02:20:26 | Sacramento Rainbow Trout | | Demoted | Edward Morgan | Edmonton SilverShoes |
| 2022-05-05 23:04:08 | Atlanta Eels | | Drop | Andrew Daniels | |
| 2022-05-05 23:02:36 | Atlanta Eels | | Drop | Luis Brodeur | |
| 2022-05-05 23:00:08 | Atlanta Eels | | Drop | Scott Preece | |
| 2022-05-05 22:59:06 | Atlanta Eels | | Drop | Robert Vance | |
| 2022-05-05 20:22:42 | Salt Lake City Night Hawks | | Drop | Damon Donovan | |
| 2022-05-05 17:20:00 | Indianapolis Tornadoes | Jason Hancock | Acquired via trade | 2nd round pick in season 34 | New York Warriors |
| 2022-05-05 17:20:00 | Indianapolis Tornadoes | 3rd round pick in season 34 | Acquired via trade | | New York Warriors |
| 2022-05-05 15:13:04 | Salt Lake City Night Hawks | | Drop | Devan McLean | |
| 2022-05-05 15:12:50 | Salt Lake City Night Hawks | | Drop | Noah Riley | |
| 2022-05-05 15:12:34 | Salt Lake City Night Hawks | | Drop | Justin Sanders | |
| 2022-05-05 13:35:10 | Detroit Gear Daddies | | Promoted | Jaylin Torres | New Orleans Hurricanes |
| 2022-05-05 13:17:28 | New Orleans Hurricanes | | Drop | Noah Washington | |
| 2022-05-05 12:03:02 | Denver Ferris Wheels | | Drop | Jamison Whitaker | |